BOC Sciences provides comprehensive LC-NMR testing services designed to meet the analytical needs of research and development across diverse industries. By integrating high-resolution chromatographic separation with advanced nuclear magnetic resonance detection, our platform delivers both qualitative and structural insights into complex mixtures. Clients rely on our expertise to address challenges in compound identification, impurity profiling, and detailed structural elucidation. Equipped with state-of-the-art instrumentation and a team of experienced specialists, we consistently deliver reliable results that accelerate scientific decision-making. Our services are recognized for technical excellence, operational flexibility, and a strong global record of customer satisfaction.
Liquid Chromatography-Nuclear Magnetic Resonance (LC-NMR) is a hybrid analytical approach that combines the separation capabilities of liquid chromatography with the molecular-level detail of nuclear magnetic resonance spectroscopy. In this technique, chromatographic separation isolates individual components within complex mixtures, which are then directly transferred to the NMR detector for detailed structural analysis. This seamless integration allows researchers to obtain comprehensive information on both the identity and structure of compounds without requiring extensive sample preparation. LC-NMR is particularly valued for its ability to characterize unknown components and reveal subtle structural variations that other techniques may overlook.
Utilizes polar stationary phases such as silica with non-polar mobile phases, ideal for separating and analyzing highly polar compounds. This method offers high-resolution chromatographic separation and detailed structural information, enabling precise identification and reliable characterization of polar molecules in complex mixtures.
Employs hydrophobic stationary phases like C18 with polar mobile phases, the most commonly used approach for small molecules, natural products, and pharmaceutical compounds. Optimized separation conditions ensure accurate structural characterization, high reproducibility, and detailed insights into compound composition and chemical environments.
Designed for charged or highly polar molecules, including peptides, oligosaccharides, and other biomolecules. This approach provides in-depth analysis of ionic interactions, molecular composition, and structural features, enabling a comprehensive understanding of complex biomolecular systems and supporting advanced analytical research.
Generates 1H and 13C NMR spectra, revealing the chemical environment and structural framework of molecules. Suitable for preliminary structure confirmation, functional group identification, and chemical shift evaluation, with optimized experiments that deliver reliable and reproducible analytical data for diverse sample types.
Includes COSY, HSQC, and HMBC techniques to resolve complex molecular structures and investigate interactions between nuclei. Particularly useful for natural products, small molecules, and functional compounds, offering tailored experiments and comprehensive structural insights for advanced molecular research.
Enables targeted analysis of specific nuclei such as 19F or 31P, providing precise structural information for molecules containing specialized elements. This service supports analysis of fluorinated, phosphorus-containing, and other niche compounds, delivering high-quality, reproducible data for research applications.
Our specialists can advise on the best LC-NMR approach for your samples, ensuring precise structure characterization and comprehensive analysis.
Please fill in this form to submit your samples and ensure smooth processing for LC-NMR testing.
LC-NMR enables precise molecular structure confirmation, impurity identification, and metabolite profiling. Generic drug developers face complex samples, strict structural verification, and limited instrument access. Our testing services provide high-resolution data, supporting R&D, process optimization, and consistent quality assurance across multiple projects and diverse pharmaceutical applications.
Natural product companies require an accurate characterization of active compounds, complex mixtures, and trace-level impurities. LC-NMR provides detailed structural and quantitative information, facilitating efficient product development, bioactive component verification, and robust quality control for plant extracts, nutraceuticals, and other high-value natural products.
Fine chemical enterprises need reaction monitoring, intermediate characterization, and impurity analysis. Diverse chemical matrices and complex molecular structures create analytical challenges. Our LC-NMR testing services deliver comprehensive molecular insights, helping optimize synthesis, ensure product quality, and improve workflow efficiency for specialty chemicals and high-value materials.
Food and functional product developers require ingredient profiling, bioactive compound identification, and composition verification. LC-NMR provides precise molecular-level insights, supporting formulation optimization, quality assessment, and functional ingredient validation. Our testing services help ensure consistent product performance and support research-driven development strategies.
Our LC-NMR services offer accurate, reliable analysis for research, production, or quality management needs. Connect with our experts to create a customized testing plan, enabling confident R&D decisions, project advancement, and robust data-driven support for complex samples across industries.
Clients submit sample details and analysis goals. Our experts evaluate feasibility and provide a tailored LC-NMR testing plan.
Clients send samples following our guidance. We log, label, and track each sample to ensure complete and traceable information.
Our team develops a customized LC-NMR protocol. Advanced instrumentation ensures accurate, reliable separation and structural analysis results.
Acquired LC-NMR data undergo rigorous processing. Experts identify peaks, confirm structures, and provide precise analytical interpretation.
A comprehensive electronic report is generated, including experimental conditions, spectra, and analytical findings for client use.
Clients receive post-report support, including data interpretation, method optimization advice, and recommendations for further analyses.
BOC Sciences offers comprehensive LC-NMR testing services that deliver reliable compound separation, accurate structural elucidation, and detailed molecular analysis, helping researchers and developers accelerate project timelines and enhance efficiency in analytical and R&D applications.
LC-NMR enables direct online analysis of chromatographic eluents, providing real-time structural information without extensive sample preparation.
Our LC-NMR approach delivers clear spectral resolution for complex mixtures, detecting low-abundance components at concentrations as low as a few milligrams per milliliter.
Combines chromatography separation with NMR detection to reveal detailed molecular structures and conformational information for small molecules and natural products.
Customized acquisition parameters and advanced data analysis allow efficient spectral interpretation, translating complex datasets into actionable insights for R&D.
BOC Sciences' LC-NMR testing enables diverse applications across pharmaceuticals, chemicals, materials, food, and environmental analysis.
Client: A specialty chemical company developing bioactive compounds
Challenge: The client required detailed structural information for complex natural product mixtures, where minor isomers and overlapping peaks made traditional methods insufficient.
Solution: BOC Sciences implemented LC-NMR to achieve real-time structural analysis during chromatographic separation. Our team optimized solvent systems, flow rates, and NMR acquisition parameters, generating high-resolution spectra and detailed chromatograms for individual components.
Outcome: The client obtained precise structural profiles of complex extracts, enabling confident selection of target compounds and accelerating downstream product development.
Client: A global manufacturer of specialty polymers
Challenge: The client needed accurate characterization of multi-component polymer additives to ensure product consistency and support R&D optimization.
Solution: BOC Sciences deployed high-performance LC-NMR workflows, combining efficient chromatographic separation with sensitive NMR detection. The team optimized column selection, gradient elution, and NMR pulse sequences to resolve overlapping components and acquire structural fingerprints simultaneously.
Outcome: The client achieved rapid identification of multiple polymer additives, enhancing formulation precision and reducing analytical bottlenecks in product development cycles.
Client: A biochemical research company focused on metabolic intermediates
Challenge: The client required detailed profiling of complex metabolic mixtures, including low-abundance and structurally similar compounds, which were difficult to resolve by conventional LC or NMR alone.
Solution: BOC Sciences applied LC-NMR with tailored separation protocols and optimized NMR acquisition strategies. Our workflow provided simultaneous qualitative and quantitative analysis, enabling detection of subtle structural variations within complex mixtures. Comprehensive spectral reports were delivered for each sample.
Outcome: The client obtained high-resolution structural insights, improved reproducibility, and reliable multi-component profiling, supporting advanced biochemical research and development efforts.
BOC Sciences' LC-NMR testing provided us with detailed structural information that was previously difficult to obtain. The integration of chromatographic separation with NMR analysis allowed us to identify subtle conformational differences with high confidence. This service has become an essential tool in our compound characterization workflow.
— Dr. M., Senior Scientist, Pharmaceutical R&D Division
The LC-NMR service offered by BOC Sciences consistently delivers robust analytical results. The team's meticulous approach to sample handling and spectral acquisition ensures that we receive interpretable and reproducible data every time. It significantly enhances our decision-making process in compound development.
— Dr. K., Principal Scientist, Specialty Chemicals Company
Utilizing BOC Sciences' LC-NMR testing has greatly improved our ability to characterize complex molecules. The combination of precise separation and high-resolution NMR analysis provides insights that traditional techniques cannot, helping us better understand our chemical entities.
— Dr. S., Head of Analytical Chemistry, Biotech Start-up
BOC Sciences' LC-NMR testing consistently delivers insightful and reliable data. Their integrated approach allows us to obtain comprehensive molecular information without extensive additional experimentation. This service has become a cornerstone in our analytical strategy.
— Dr. J., Research Scientist, Agrochemical Development Firm
