C-H Activation

C-H Activation

Carbon–hydrogen bond activation is used to replace hydrogen with carbon-X (X is usually carbon, oxygen or nitrogen) via C-H cleavage process which was first reported at 1955. C-H activation chemistry has paved novel way to transform the chemical synthesis through the conversion of cheap and abundant resource like alkanes, into valuable functionalized organic compounds or even the structural complex molecules. Also thanks to C-H activation, possible reaction has become available. This methodology has the potential to be used in many different areas of chemistry ranging from relatively small molecules like drug candidates, to complex polydisperse organic compounds such as polymers.

C-H Activation Figure 1. C-H functionalization mechanisms

Application of C-H Activation

The product in the C-H funtionalization reaction is a common scaffold for multiple natural products, including hapalindole Q and ambiguine H. The core structure can be made through a C-C bond (blue bond in product) formation via C-H activation. Since heterocyclic are common structures in drug molecules and natural products, astute and innovative applications of this strategy have been blossoming in diverse fields, ranging from materials science and luminescent devices, to streamlining the drug-discovery process. Furthermore, owing to the latent character of C-H bonds, harsh reaction conditions are often required for their direct functionalization. The high reaction temperatures, strongly acidic conditions and the use of powerful oxidizing agents can be a serious restriction. Additionally, practical and widely applicable transformations need to offer high functional group tolerance.

Why Choose BOC Sciences?

BOC Sciences provides high-quality, low-cost, high-tech products to customers around the world. We has employed a dedicated staff of professional chemists to help you develop the most efficient process for C-H activation. With diverse state-of-the-art technologies and approaches, clients’ synthetic route can be developed and optimized in the most cost effective way. Each step of product synthesis is subject to BOC Sciences’ stringent quality control. Typical delivery specifications include:

  • In quantities of several milligrams up to 100 grams.
  • Additional analyses, such as stability determination, impurity analysis, and residual solvents etc.
  • With diverse state-of-the-art technologies and approaches.
  • Quality assurance: HPLC chromatogram and Mass spec analysis.
  • Overnight shipping with suitable packs.


  1. Chen, D. Y. K., & Youn, S. W. (2012). C H Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products. Chemistry-A European Journal, 18(31), 9452-9474.
  2. Wencel-Delord, J., & Glorius, F. (2013). C–H bond activation enables the rapid construction and late-stage diversification of functional molecules. Nature chemistry, 5(5), 369.

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