Nano to Micro Particles Biconjugation

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Nano to Micro Particles Biconjugation

Nanoparticles (NPs) or microparticles are those tiny vehicles having a particle size ranging from 1 to 100 nm or 0.1 to 100 µm. According to the constructing materials, they can be classified into carbon-based NPs, metal NPs, ceramics NPs, semiconductor NPs, polymeric NPs, and lipid-based NPs. Development of NPs and microparticles have been widely applied in a wide range of healthcare fields such as drug delivery and building of controlled release systems. By encapsulation of active ingredients (APIs) within their inner cores, the cytotoxicity of drugs to normal tissues and risk of immunogenicity can be significantly reduced. Additionally, modification of the surface of nanoparticles or microparticles with certain biological molecules such as peptides, aptamers, antibodies, is thought to be an effective strategy to achieve targeting disease drug delivery.

Nano to Micro Particles BiconjugationFigure 1. Schematic representation of a nanoparticle with PEG molecules (on the left, light grey), streptavidin (green), transferrin (blue), antibody (IgG, purple), albumin (red), single-stranded DNA1.

Below is a list of our Nano to Macro Particles Bioconjugation Services (include but not limited to the following):

Antibody-particle conjugation

Combination of the unique physicochemical properties of nano to micro particles and the high selectivity and specificity of antibodies make the antibody significantly facilitate the application of antibody-particle conjugates in a broad range of applications such asmedical diagnostics and drug delivery.

Coating the surface of particles with polyethylene glycol (PEG) can potentially reduce adhesive interactions of particles with intracellular components, which contributes to an improved systemic circulation of your products.

Functionalization of nano to micro particles with a tumor-homing peptide or aptamer can significantly improve the accumulation of anti-cancer drugs in tumor tissues and finally lead to an enhanced pharmacodynamics.

Gold nanoparticles become extremely interesting materials due to their enhanced optical, chemical and electrical properties. Their ability to form robust conjugates with biomolecules has given proteomics a new tool to improve aspects where the current methods to study proteins and their interactions in living cells cannot achieve the success required.

The development of screening assays continues to be an active area of research in molecular diagnostics. Fluorescent microspheres conjugated to biomarkers (nucleic acids, proteins, lipids, carbohydrates) and analyzed on flow cytometer instruments offered a new approach for multiplexed detection platform in a suspension format.

Additional conjugates such as fluorescent dye labeled particles, protein-particle conjugates, transferrin/albumin-particle conjugates, streptavidin-particle conjugates and other molecules modified particles can be offered according to your special needs.

Why Choose BOC Sciences?

Your bioconjugate designing scheme and manufacturing process will be thoroughly optimized by our experts to produce the most stable and highest quality biological products. More importantly, our team of conjugation scientists are capable of providing custom conjugate formulation services at any scale for your needs and full purification will be offered as a follow-up service. Contact our experts to design or optimize your synthetic method timely and efficiently.

References

  1. Khan, I., Saeed, K. and Khan, I. (2017) ‘Nanoparticles: properties, applications and toxicities’, Am. J. Chem.
  2. Ferreira Soares, D. C., Oda, C. M. R., Monteiro, L. O. F., de Barros, A. L. B., & Tebaldi, M. L. (2018). Responsive polymer conjugates for drug delivery applications: recent advances in bioconjugation methodologies. Journal of drug targeting, 1-12.
  3. Li, P. Y., Fan, Z., & Cheng, H. (2018). Cell membrane bioconjugation and membrane-derived nanomaterials for immunotherapy. Bioconjugate chemistry29(3), 624-634.
  4. Bazak, R., Houri, M., El Achy, S., Kamel, S., & Refaat, T. (2015). Cancer active targeting by nanoparticles: a comprehensive review of literature. Journal of cancer research and clinical oncology141(5), 769-784.
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