Chiral Building Blocks

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Chiral Building Blocks

Building block is a term in chemistry which is used to describe a virtual molecular fragment or a real chemical compound the molecules of which possess reactive functional groups. As for chiral building blocks, they are valuable intermediates in the syntheses of natural products and pharmaceuticals. With the development of new drugs, it increasingly requires the use of chiral building blocks for lead optimization, and even on early stages-in search for efficient compounds. This is mainly because of the fact that at almost all the biological targets are chiral, and the drug-receptor interaction requires strict match of chirality.

Example of Chiral Building Blocks at BOC Sciences

  • Amines (source of chirality –asymmetric synthesis, chiral pool):

Chiral Building Blocks

  • Alcohols (source of chirality –catalytic asymmetric synthesis, enatioseparation):

Chiral Building Blocks

  • Carboxylic Acids (source of chirality –asymmetric synthesis, chiral pool):

Chiral Building Blocks

  • Alkaloids (source of chirality –asymmetric synthesis):

Chiral Building Blocks

  • Esters (source of chirality –asymmetric synthesis):

Chiral Building Blocks

  • Amides (source of chirality –asymmetric synthesis):

Chiral Building Blocks

  • Amino Alcohols (source of chirality –asymmetric synthesis):

Chiral Building Blocks

Why Choose BOC Sciences?

BOC Sciences has experts with extensive experience in chiral building blocks synthesis services. In the last decades, chiral optically pure building blocks have long been considered as less available than non-chiral-hence the widespread common opinion that non-chiral building blocks are more preferable than chiral, especially on early stages of drug development. BOC Sciences would like to refute this opinion by offering a large selection of easily available, optically pure, functionalized chiral building blocks. We can provide various types of chiral building blocks, including chiral secondary and tertiary alcohols, carboxylic acids, amines, alkaloids, lactones, esters and amino alcohols, so that laboratory based researchers may discover and build new drug molecules. Moreover, all the synthesized chiral building blocks are analysed for optical purity using modern chromatographic, NMR and other techniques, with a quick turnaround time.

References

  1. Kaupmann, K., Huggel, K., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., ... & Bettler, B. (1997). Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors. Nature386(6622), 239.
  2. Maury, J., Zawodny, W., & Clayden, J. (2017). Stereospecific intramolecular arylation of 2-and 3-pyridyl substituted alkylamines via configurationally stable α-pyridyl organolithiums. Organic letters19(3), 472-475.
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