Protection or Derivatization

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Protection or Derivatization

Derivatization is desirable for its reliable reaction proceeds to completion, the stable products and degradation products. Especially in the synthesis of structurally complex compounds, designing the synthetic strategies such as selection of protecting groups and the efficient deprotection process are key steps to achieve. It is expected that a wide variety of protecting agents are available.

Below is a list of our available protecting groups (include but not limited to the following):

Acyl protecting groups

Acyl protecting groups are used for the protection of hydroxy groups and amino groups. It is stable under acidic conditions and oxidative conditions. Acyl protecting groups are deprotected under basic conditions or reductive conditions. Acylation can be used to prevent rearrangement reactions that would normally occur in alkylation. Then the carbonyl is deprotected by Clemmensen reduction or a similar process.

Trimethylsilane or its derivative which are also employed in the protection process for silicon-based has appealing deviating reactivity, boiling point, melting point, aggregate state which reduces complicating interference. A trimethylsilyl group (TMS) consists of three methyl groups bonded to a silicon atom [−Si (CH3)3]. It was common seen as temporary protecting groups during chemical synthesis or some other chemical reactions such as protection for alcohols. Also, TMS is susceptible in the reaction with HF-based or HCl reagents.

When it comes to amino group protection, the tert-butyloxycarbonyl protecting group (BOC group) is widely used in drug synthesis. With stable basic hydrolysis conditions and catalytic reduction conditions, Boc is a powerful strategy in specific process. BOC protection is available to various solutions such as: water THF, and approachable temperature (between 0℃ and 40℃, even at ambient temperature). Then hydrochloric acid is an effective way in the BOC deprotection.

Methoxymethyl chloroalkyl ether or methoxymethylation compound is employed for the introduction of the methoxymethyl (MOM) protecting group in organic synthesis. MOM can be cleaved with a range of Lewis acids, including but are not limited to: dichloromethane, methanol, and formic acid.

Why Choose BOC Sciences?

BOC Sciences provides high-quality, low-cost, high-tech products to customers around the world. We has employed a dedicated staff of professional chemists to help you develop the most efficient process for synthesis of derivatization. With diverse state-of-the-art technologies and approaches, clients’ synthetic route can be developed and optimized in the most cost effective way. Each step of product synthesis is subject to BOC Sciences’ stringent quality control. Typical delivery specifications include:

  • In quantities of several milligrams up to 100 grams.
  • Additional analyses, such as stability determination, impurity analysis, and residual solvents etc.
  • With diverse state-of-the-art technologies and approaches.
  • Quality assurance: HPLC chromatogram and Mass spec analysis.
  • Overnight shipping with suitable packs.

Reference

  1. Vollhardt, Peter; Schore, Neil (2014). Organic Chemistry: Structure and Function (7th ed.). 714-715.
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