At BOC Sciences, we offer comprehensive LC-HRMS testing services designed to meet the analytical needs of researchers and organizations across diverse industries. Our services include high-resolution analysis of small molecules, natural products, metabolites, and complex chemical compounds. Leveraging state-of-the-art instrumentation and an experienced analytical team, we provide accurate identification, structural elucidation, impurity profiling, and tailored data interpretation. Our clients consistently praise our precision, flexibility, and professional support. Whether you require routine testing or complex analytical solutions, BOC Sciences delivers reliable, high-quality results that empower informed scientific decision-making.
LC-HRMS (Liquid Chromatography–High Resolution Mass Spectrometry) testing is an advanced analytical approach that combines efficient separation with precise molecular detection. In this technique, liquid chromatography first separates complex mixtures into individual components based on properties such as polarity, molecular size, or hydrophobicity. The separated compounds are then ionized and analyzed by high-resolution mass spectrometry, which measures their mass-to-charge ratios with exceptional accuracy and sensitivity. This integration allows scientists to distinguish molecules with minute mass differences, reveal structural features, and perform reliable qualitative, quantitative, and impurity analyses. As a result, LC-HRMS has become a powerful tool for characterizing complex chemical and biological samples.
We precisely quantify predefined target compounds, including metabolites, drugs, and natural products, using optimized LC-HRMS workflows. This approach ensures high sensitivity, reproducibility, and reliable results for research, residue detection, and environmental monitoring.
We capture comprehensive chemical profiles without predefined targets, enabling discovery of unknown or novel compounds. Our advanced LC-HRMS acquisition and data processing provide accurate identification, supporting metabolomics, food safety, and unknown contaminant screening.
We screen predefined lists of suspect compounds from databases or literature without requiring standards. Using high-resolution LC-HRMS, we efficiently detect potential contaminants, supporting food safety, environmental monitoring, and drug residue surveillance.
Tell us about your analytical requirements, and our experts will propose the optimal LC-HRMS workflow for your study.
Samples requiring LC-HRMS testing, with or without prior preparation, can be submitted using our Sample Submission Form.
Our LC-HRMS service platform offers a wide range of high-resolution mass spectrometry instruments equipped with various ionization sources, capable of analyzing compounds with diverse polarity and stability. This ensures precise identification, quantification, and advanced research applications. Key Capabilities Include:
| Ionization Source | Target Compounds | Applications |
| ESI-HRMS | Polar or thermally labile molecules (metabolites, drugs, peptides) | Ideal for sensitive biological and metabolomic analysis |
| APCI-HRMS | Moderately polar small molecules (steroids, fat-soluble vitamins) | Suitable for lipophilic compound quantification |
| APPI-HRMS | Non-polar compounds (PAHs, petroleum additives) | Efficient analysis of hydrophobic and aromatic molecules |
| nano-ESI-HRMS | Low-volume samples, proteomics, single-cell metabolomics | Nanoliter flow rates improve sensitivity for limited samples |
| HESI-HRMS | Heated ESI, complex matrices such as oral liquids | Enhances desolvation efficiency for complex or viscous samples |
Clients submit sample information and testing goals online. Our experts provide tailored advice, ensuring the analysis plan meets specific project needs effectively.
Upon plan confirmation, samples are received and logged under strict protocols. Necessary preparation ensures optimal conditions for accurate LC-HRMS analysis.
Our team performs high-sensitivity, high-precision analysis using advanced liquid chromatography–high resolution mass spectrometry systems, following rigorous laboratory standards.
Raw data is processed using specialized software. Multiple quality checks ensure reliable, consistent results, providing a solid foundation for reporting.
A structured report is generated, including clear methodology, visual data, and analysis results, enabling straightforward interpretation and application.
Final reports are securely delivered to clients. Our technical team provides ongoing support to answer questions and clarify analytical findings.
BOC Sciences' LC-HRMS testing services deliver highly accurate mass analysis and structural characterization for diverse compounds, enabling efficient data acquisition and supporting the advancement of research and development initiatives.
LC-HRMS precisely detects complex molecules, including low-abundance compounds, with mass measurement error typically within 2–5 ppm, ensuring highly reliable identification.
Provides in-depth insights into molecular structures and fragmentation patterns, delivering detailed information to support research and development decisions.
Tailored LC-HRMS workflows are designed based on sample characteristics and analytical requirements, maximizing data quality across diverse sample types and complexities.
Combining cutting-edge software with sophisticated analytical strategies, complex high-resolution datasets are converted into actionable insights, accelerating project progress.
BOC Sciences' LC-HRMS services support multiple application areas across drug discovery, preclinical development, and formulation, including but not limited to the following.
Client: A leading environmental research institute in North America
Challenge: The client needed precise identification and quantification of trace-level organic pollutants in complex water and soil matrices, where traditional methods often failed to resolve overlapping compounds.
Solution: BOC Sciences implemented ultra-high-performance LC coupled with HRMS, utilizing optimized gradient elution methods and accurate mass detection. Our team tailored sample preparation protocols and applied advanced spectral deconvolution software to separate and quantify structurally similar contaminants.
Outcome: The client achieved highly reproducible detection of multiple pollutants, enhanced compound resolution, and received comprehensive reports with clear quantitative metrics, enabling data-driven environmental assessments.
Client: A global nutraceutical company
Challenge: The client required comprehensive profiling of complex botanical extracts to identify minor bioactive components while maintaining structural specificity and reducing analytical noise.
Solution: BOC Sciences deployed LC-HRMS with high-resolution Orbitrap analyzers and optimized electrospray ionization conditions. We developed custom chromatographic separation strategies and integrated full-scan and data-dependent MS/MS workflows to generate detailed molecular fingerprints of the extracts.
Outcome: The client obtained accurate molecular identification of both major and minor constituents, with high-confidence structural annotation, supporting product development and quality control initiatives.
Client: A leading biotechnology company focused on metabolic profiling
Challenge: The client needed sensitive and untargeted detection of a broad spectrum of endogenous metabolites in complex cell and tissue samples, with high dynamic range and minimal matrix interference.
Solution: BOC Sciences applied advanced LC-HRMS platforms with high-resolution time-of-flight (TOF) analyzers, using optimized polarity switching and automated data processing pipelines. Our team implemented robust internal standard strategies and spectral alignment techniques to ensure precise metabolite identification and quantification.
Outcome: The client achieved comprehensive metabolomic coverage, increased confidence in metabolite identification, and obtained high-quality, publication-ready datasets that supported key research initiatives and compound discovery programs.
BOC Sciences' LC-HRMS testing service provides exceptionally detailed compound identification and characterization. The depth of their mass spectrometric analysis allowed our team to confidently explore complex molecular structures and detect subtle variations in our samples. Their analytical insight has significantly enhanced our R&D strategies.
— Dr. M., Senior Scientist, Specialty Chemicals Firm
We have repeatedly relied on BOC Sciences' LC-HRMS services, and each project consistently produces robust and reproducible data. Their careful calibration and method optimization ensure that results are dependable, which has greatly streamlined our internal decision-making processes.
— Mr. K., Head of Analytical Development, Agricultural Biotechnology Company
The LC-HRMS team at BOC Sciences demonstrates outstanding expertise in mass spectrometry. Their ability to handle challenging matrices and provide comprehensive spectral interpretation has been invaluable for our discovery programs, enabling us to make informed, data-driven decisions with confidence.
— Dr. S., Lead Scientist, Natural Product Research Institute
BOC Sciences' LC-HRMS service goes beyond mere data generation; their analysts provide insightful interpretation and guidance that enhance our understanding of complex samples. This collaborative approach has proven critical in advancing our molecular research initiatives.
— Dr. H., Principal Investigator, Biotech Start-up
