Nanosuspension/Microemulsion

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Nanosuspension/Microemulsion

One of the main problems associated with poorly soluble drugs is the low bioavailability and poor solubility. Formulation as a nanosuspension is an attractive and promising alternative to address these issues. Nanosuspensions consist of poorly soluble drugs that are insoluble in water and oil, and the solid particles have a particle size distribution typically less than 1 micron, which enhances the solubility of poorly water soluble drugs as well as lipid media. Nanosuspensions are simple to prepare and have been developed as promising candidates for the effective delivery of hydrophobic drugs, typically for oral and topical use or parenteral and pulmonary administration. The nanosuspension not only solves the problem of poor solubility and bioavailability, but also changes the pharmacokinetics of the drug, thereby improving the safety and effectiveness of the drug.

Advantages of Nanosuspensions

  • Simple preparation
  • Increased dissolution rate and saturated solubility
  • Improved adhesion
  • Increased bioavailability, resulting in reduced doses,
  • Easy Large-scale production
  • Enhance the solubility and bioavailability of drugs
  • Suitable for hydrophilic drugs
  • Higher drug loading can be achieved
  • Dose reduction is possible
  • Enhance the physical and chemical stability of drugs
  • Provide a passive drug targeting
  • Improvement of dissolution velocity
  • Increased saturation solubility
  • Improved bioadhesivity, versatility in surface modification
  • Ease of postproduction processing

Below is a list of our available Nanosuspension/Microemulsion Technologies (include but not limited to the following):

  • High pressure homogenization (Dissocubes)
  • Solvent–Antisolvent method
  • Supercritical fluid processes
  • Emulsification-solvent evaporation
  • Dry Co-Grinding

Why Choose BOC Sciences?

BOC Sciences is developing a range of formulations using nanosuspension technology, including drug delivery systems, controlled release systems and more. These products present multiple challenges to product characterization. However, we have experienced analysts and nanoparticle engineering professionals who have comprehensive R&D or Good Manufacturing Practice (cGMP) analytical capabilities for nano-sized particle or suspension systems. In addition, we offer comprehensive expertise with quality guaranteed to help you meet and exceed quality, safety and regulatory standards.

References

  1. Patel, V. R., & Agrawal, Y. K. (2011). Nanosuspension: An approach to enhance solubility of drugs. Journal of advanced pharmaceutical technology & research2(2), 81.
  2. Mukesh, D. (2012). Nanosuspension technology for solubilizing poorly soluble drugs. Int. J. Drug Dev. Res4(4), 40-49.
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