Chiral Ligands

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Chiral Ligands

A logical extension about the application of chiral ligands in stereoselective catalysis has been developed. In general, ligands design in asymmetric catalysis is guided by several simple concepts and principles. For instance, the design of chiral ligands is frequently based on C2-symmetry in order to reduce the number of diastereomeric intermediates and transition states which play a role in the catalytic cycle. This approach has been vindicated by the successful development of several large families of (“privileged”) chiral ligands which nowadays belong to the basic “tool kit” of asymmetric catalysis, such as chiral diphosphines, salen derivatives and bisoxazolines. These privileged families of ligands possess characteristic properties which lead to the induction of high stereoselectivities in their catalytic reactions. As a result, the syntheses of chiral ligands have evolved into a very dynamic, rapidly growing area of research, attracting an increasing number of chemists from various disciplines.

Chiral Ligands

Below is a list of our available chiral Ligands (include but not limited to the following):

Chiral N-heterocyclic carbene ligands

With a significant number of highly selective chiral catalysts based on chiral NHCs, several general trends in the design of new NHC-containing molecular catalysts for stereoselective transformations in organic synthesis emerge. Six large families of chiral N-heterocyclic carbine ligands have thus recently emerged: NHCs with N-substituents containing centres of chirality; NHC ligands containing chiral elements within the N-heterocycle; NHC ligands containing an element of axial chirality; Carbenes containing an element of planar chirality; Carbenes joined by a chiral trans-cyclohexanediamine ligand backbone; Carbenes incorporating oxazoline units.

The ligands used in asymmetric H-transfer feature various combinations of nitrogen, oxygen, phosphorus, sulfur and even arsenic as the donor atoms. They can be bidentate, tridentate and tetradentate. More appropriately ligands can be classified as anionic or neutral, depending on whether or not they possess a protonated donor centre-XH of appropriate acidity.

Hydrogenation of R-dehydroamino acid derivatives has been a typical reaction to test the efficiency of new chiral phosphorus ligands. Several chiral ligands such as PYRPHOS, EtDuPhos, TangPhos, DPAMPP, and BoPhoz have been demonstrated to be very efficient ligands for hydrogenation of R-dehydroaminoacid derivatives in terms of both high enantioselectivity and reactivity.

Why Choose BOC Sciences?

BOC Sciences has extremely copious experience in regard to the syntheses of chiral ligands. We can provide a great deal of chiral ligands and its applications. We have a large number of instruments, as well as enormous experienced and professional experts. Our company has developed into first-class modern enterprise with professional knowledge and excellent technical staff. Welcome to get in touch with us, we will provide friendly and professional service for you. Simultaneously, we will continuously improve our professional knowledge and skills, making our company more trustworthy.

References

  1. Tang, W., & Zhang, X. (2003). New chiral phosphorus ligands for enantioselective hydrogenation. Chemical Reviews103(8), 3029-3070.
  2. Gladiali, S., & Alberico, E. (2006). Asymmetric transfer hydrogenation: chiral ligands and applications. Chemical Society Reviews35(3), 226-236.
  3. Wang, X., Wei, C., Su, J. H., He, B., Wen, G. B., Lin, Y. W., & Zhang, Y. (2018). A Chiral Ligand Assembly That Confers One‐Electron O2 Reduction Activity for a Cu2+‐Selective Metallohydrogel. Angewandte Chemie130(13), 3562-3566.
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