BOC Sciences provides cost-effective screening library-related services, whether it is the synthetic customer-designed compound libraries or design compound libraries to advance the customer's project. Our compound library synthesis team of multidisciplinary experts can do well to meet the requirements of our customers.
New drug development is derived from the screening of a large number of compounds with different chemical structures, and the screening of leading compounds to further optimize. To meet the requirements of new drug development, BOC Sciences has constructed several small molecular compound libraries and can design the library according to the specific requirements. Our compound library has the advantages of the diverse core structure, high quality, novel structure, the high proportion of active compounds and so on.
Below is a list of our available Screening Libraries Services (include but not limited to the following):
High Throughput Screening (HTS) is a scientific experimental method that sets foot in both biology and chemistry fields, which is the reason why HTS is especially suitable for drug discovery. High throughput screening enables researchers to rapidly perform millions of chemical, genetic, or pharmacological tests by using robotic technology, data processing/control software, liquid processing devices and sensitive probes. Through this process, it is possible to swiftly identify active compounds, antibodies, or genes that regulate specific biological pathways. The results of these experiments provide a starting point for drug design and understanding of specific biochemical processes in biology.
In the field of drug discovery, fragment-based drug design (FBDD) methods are rapidly emerging as alternative methods for high-throughput screening. Molecular drug design is to cut the known drug molecules into pieces. Some of these molecular fragments may inherit all or part of the original pharmacological properties of these active molecules, and then be converted into a better drug. The core fragment of molecules with low molecular weight, according to the experimental results, usually binds to the binding site weakly. After further structural optimization, compounds with better properties would be obtained.
Activity-based libraries are designed to classify and collect biologically active molecules according to their different potential applications, such as anti-inflammatory databases and anti-cancer databases. The libraries are designed to maximally fit specified activity areas, using combination of validated descriptors and compound properties.
Custom libraries help customers to select diverse compounds from BOC Sciences and specify desired quantities. BOC Sciences’ service team and scientifically trained personnel will be glad to help customers create a unique compound library to meet exact screening requirements.
The focus of library design has transferred toward designing libraries based on numbers of properties simultaneously, for example, diversity and drug-like physicochemical properties. These libraries can produce HTS hits with properties that make them suitable to be taken forward into medicinal chemistry.
The screening libraries at BOC Sciences are made up of twenty-one libraries that can be used for drug discovery, laboratory drug screening, drug target identification, and other drug-related applications. Each library can be screened individually or used in conjunction with other libraries so that it can be tailored to the requirements of the screening project and cover the chemical space to the maximum extent possible. To maximize the chances of finding a hit. And we will continue to produce novel, lead-like and drug-like screening compounds. BOC Sciences' libraries contain diverse biological-and pharmacological-functioning compounds that can be used as the high content of screening materials. To ensure the quality, a complete appraisal report or certificate of analysis of each compound purity and chemical structure is also provided by BOC Sciences.
BOC Sciences provides bioassays in: