BOC Sciences's R&D team has years of experience in chiral synthesis and can provide comprehensive synthesis services. BOC Sciences focuses on customized synthetic services, which can efficiently carry out pilot scale-up, technical verification and commercial production, ensuring product quality stability and safety and saving time and cost for customers.
The mirror image of a chiral molecule is an enantiomer. As shown below, a pair of enantiomers is structurally symmetrical but not completely overlap in chemistry.
Chiral synthesis, or enantioselective synthesis, can be used to discover innovative drugs and materials, and has been widely used in the development of pharmaceutical products and other biologically active substances. For example, axially chiral biaryl is one of the most important activity structures of many drug molecules. It can be synthesized by metal-mediated cross coupling, de novo construction of an aromatic ring, point-to-axial chirality transfer or atropselective transformation of an existing biaryl.
Biocatalysis is the use of biological compounds (enzymes or live cells) to perform and speed up chemical transformations. Advantages of biocatalysts are commonly recognized by the industry. Yeast is a typical biocatalyst for the chiral reduction of ketones.
Chiral pool synthesis is one of the simplest approaches for chiral synthesis. The desired target molecule is obtained by successive reactions of chiral starting materials with achiral reagents. So, chiral pool synthesis is necessary if a new chiral species will be created in SN2 reaction.
Generally, enantioselective catalysis involves chiral coordination complexes. The catalysts are rendered chiral by using chiral ligands. A typical example of enantioselective catalysis is asymmetric hydrogenation, which could reduce a wide range of functional groups.
Organocatalysis is a catalysis that increases the rate of chemical reactions, but the organic catalysts only consist of carbon, hydrogen, sulfur and other non-metal elements. If the organocatalyst is chiral, enantioselective synthesis can be achieved.
The chiral auxiliary is a compound or unit temporarily added to organic synthesis to control the synthesis of stereochemistry. By adding the chiral auxiliary, the prochiral substrate can be transformed into a chiral product. Moreover, the auxiliary can typically be recycled for future use.
Building block is a term in chemistry used to describe a virtual molecular fragment or a real chemical compound whose molecules possess reactive functional groups. As for chiral building blocks, they are valuable intermediates in the synthesis of natural products and pharmaceuticals.
Chiral catalysts can be applied in asymmetric synthesis such as alkylation, Diels-Alder reaction, asym-metric reduction, hydroformylation, epoxylation, and dihydroxylation. The relationship between the chiral catalyst and the reaction system is just like the relationship between a lock and a key, which is highly selective.
The design of chiral ligands is frequently based on C2-symmetry to reduce the number of diastereomeric intermediates and transition states that play a role in the catalytic cycle.
The chiral resolution, as an important tool in the production of optically active drugs, is a process for the separation of racemic compounds into their enantiomers in the aspect of stereochemistry.
At BOC Sciences, we provide various types of synthesis methods including biocatalysis, chiral pool synthesis, enantioselective catalysis, chiral auxiliaries catalysis, and organocatalysis. We also use multiple techniques (NMR, LCMS, GCMS, X-ray) to analyze compounds after completing the chiral synthesis. Our experts will work with you to optimize the synthetic routes and approaches. According to your needs and the properties of chemical substances, a wide range of custom services are available in our laboratory.