Chiral Synthesis

Chiral Synthesis

BOC Sciences' R&D team has years of experience in chiral synthesis and can provide comprehensive synthesis services. BOC Sciences focuses on customized synthetic services, which can efficiently carry out pilot scale-up, technical verification and commercial production, ensuring product quality stability and safety and saving time and cost for customers.

Our Advantages

  • Strict quality control platform to conduct quality identification of synthetic products.
  • Providing chiral-related synthesis services and high-quality, high-purity compounds.
  • Years of experience in compound custom synthesis to meet the individual customization needs of customers.
  • Providing the most thoughtful and comprehensive service at the best price.

The mirror image of a chiral molecule is an enantiomer. As shown below, a pair of enantiomers is structurally symmetrical but not completely overlap in chemistry.

Chiral Synthesis

Chiral synthesis, or enantioselective synthesis, can be used to discover innovative drugs and materials, and has been widely used in the development of pharmaceutical products and other biologically active substances. For example, axially chiral biaryl is one of the most important activity structures of many drug molecules. It can be synthesized by metal-mediated cross coupling, de novo construction of an aromatic ring, point-to-axial chirality transfer or atropselective transformation of an existing biaryl.

Methods of Chiral Synthesis

Chiral Synthesis

Biocatalysis

Biocatalysis is the use of biological compounds (enzymes or live cells) to perform and speed up chemical transformations. Advantages of biocatalysts are commonly recognized by the industry. Yeast is a typical biocatalyst for the chiral reduction of ketones.

Chiral pool synthesis

Chiral pool synthesis is one of the simplest approaches for chiral synthesis. The desired target molecule is obtained by successive reactions of chiral starting materials with achiral reagents. So, chiral pool synthesis is necessary if a new chiral species will be created in SN2 reaction.

Enantioselective catalysis

Generally, enantioselective catalysis involves chiral coordination complexes. The catalysts are rendered chiral by using chiral ligands. A typical example of enantioselective catalysis is asymmetric hydrogenation, which could reduce a wide range of functional groups.

Organocatalysis

Organocatalysis is a catalysis that increases the rate of chemical reactions, but the organic catalysts only consist of carbon, hydrogen, sulfur and other non-metal elements. If the organocatalyst is chiral, enantioselective synthesis can be achieved.

Our Services

Chiral Auxiliaries

The chiral auxiliary is a compound or unit temporarily added to organic synthesis to control the synthesis of stereochemistry. By adding the chiral auxiliary, the prochiral substrate can be transformed into a chiral product. Moreover, the auxiliary can typically be recycled for future use.

Chiral Building Blocks

Building block is a term in chemistry used to describe a virtual molecular fragment or a real chemical compound whose molecules possess reactive functional groups. As for chiral building blocks, they are valuable intermediates in the synthesis of natural products and pharmaceuticals.

Chiral Catalysts

Chiral catalysts can be applied in asymmetric synthesis such as alkylation, Diels-Alder reaction, asym-metric reduction, hydroformylation, epoxylation, and dihydroxylation. The relationship between the chiral catalyst and the reaction system is just like the relationship between a lock and a key, which is highly selective.

Chiral Ligands

The design of chiral ligands is frequently based on C2-symmetry to reduce the number of diastereomeric intermediates and transition states that play a role in the catalytic cycle.

Chiral Resolution

The chiral resolution, as an important tool in the production of optically active drugs, is a process for the separation of racemic compounds into their enantiomers in the aspect of stereochemistry.

Our Project Management

Chiral Synthesis

Each step of product synthesis is subject to BOC Sciences’ stringent quality control. Typical delivery specifications include:

  • The quantity varies from several milligrams to 100 grams.
  • Providing additional analysis, such as stability determination, impurity analysis , and residual solvents analysis etc.
  • With diverse state-of-the-art technologies and approaches.
  • Quality assurance: HPLC chromatogram and mass spec analysis.
  • Overnight shipping with suitable packs.

Why Choose BOC Sciences?

At BOC Sciences, we provide various types of synthesis methods including biocatalysis, chiral pool synthesis, enantioselective catalysis, chiral auxiliaries catalysis, and organocatalysis. We also use multiple techniques (NMR, LCMS, GCMS, X-ray) to analyze compounds after completing the chiral synthesis. Our experts will work with you to optimize the synthetic routes and approaches. According to your needs and the properties of chemical substances, a wide range of custom services are available in our laboratory.

References

  1. Jolliffe, J. D., Armstrong, R. J., & Smith, M. D. (2017). Catalytic enantioselective synthesis of atropisomeric biaryls by a cation-directed O-alkylation. Nature Chemistry, 9(6), 558.
  2. Silverman, R. B., & Xue, F. (2015). U.S. Patent No. 9,212,161. Washington, DC: U.S. Patent and Trademark Office.
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