Semi-Synthesis and Total-Synthesis of Natural Product

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Semi-Synthesis and Total-Synthesis of Natural Product

Natural products are the components or metabolites of animals, plants, mineral substance, insects, marine organisms and microorganisms, as well as a lot of endogenous chemicals in humans and animals. The basic substances compose the natural products including proteins, peptides, amino acids, nucleic acids, enzymes, monosaccharides, oligosaccharides, polysaccharides, sugars, etc.

Semi-Synthesis and Total-Synthesis of Natural Product Fig 1. Synthesis Route Design of Compound oxynitidine (Yang Shi et al. 2018)

Below is a list of our featured custom synthesis of natural product (include but not limited to the following):

Benzo-oxygen Heterocyclic Natural Products

Benzo-oxygen heterocyclic natural products have abundant sources, complex structures, huge numbers and obvious biological activities in the nature, since being discovered, they have become the focus researches of organic synthesis,and have got important applications in the field of medicine, pesticide and materials.

Sesquiterpenoid natural products play an important role in pesticide insecticides, insect antifeedants and anti-hypertension. However, there are many kinds of natural antifeedant agents, including terpenes, alkaloids, and glycosides and so on. Among them, the use of alkene antifeedant is the main natural antifeedant towel. So it is important for synthesis of bicyclic sesquiterpenes.

Daphnane diterpenoids usually embrace a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C3, C4, C5, C9, C13, C14, C20 and some special ones have a characteristic orthoester motif located at C9, C13, C14. The in-vitro and in-vivo experiments of these compounds have shown that they bear a wide range of biological activities including anti-HIV, anticancer, anti-leukemic, neurotrophic, pesticidal and cytotoxic effects.

Lepadins are a growing family of cis-decahydroquinoline alkaloids. Eight lepadin alkaloids have been isolated from several marine sources including the tunicate clavelina lepadiformis and its predator the flatworm prostheceraeus vittatus (lepadins A−C). It is important for synthesis of (-)-lepadins A-C.

Why Choose BOC Sciences?

BOC Sciences provides high-quality, low-cost, high-tech products to customers around the world. We has employed a dedicated staff of professional chemists to help you develop the most efficient process for synthesis of natural products. With diverse state-of-the-art technologies and approaches, clients’ synthetic route can be developed and optimized in the most cost effective way. In addition, various advanced techniques (NMR, LCMS, GCMS, HPLC, IR, and X-ray) are available in our laboratory to ensure your requirements can be met with high quality and timely.

References

  1. Shi, Y., Zhang, L., Lan, J., Zhang, M., Zhou, F., Wei, W., & You, J. (2018). Oxidative C-H/C-H Cross‐Coupling Reactions between N‐Acylanilines and Benzamides Enabled by a Cp*‐Free RhCl3/TFA Catalytic System. Angewandte Chemie130(29), 9246-9250.
  2. Yu, Y. C., Zhu, S., Lu, X. W., Wu, Y., & Liu, B. (2015). Enantioselective Synthesis of Four Natural Homoisoflavonoids. European Journal of Organic Chemistry2015(22), 4964-4972.
  3. Rong, L., Jing, F., & Bo, L. (2016). Synthetic Progress of Daphnane-type Diterpenoids. ACTA CHIMICA SINICA74(1), 24-43.
  4. Li, X., Hu, L., Jia, J., Gu, H., Jia, Y., & Chen, X. (2017). A Stereoselective Approach toward (−)-Lepadins A–C. Organic letters19(19), 5372-5375.
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