Natural products are the components or metabolites of animals, plants, mineral substance, insects, marine organisms and microorganisms, as well as a lot of endogenous chemicals in humans and animals. The basic substances compose the natural products including proteins, peptides, amino acids, nucleic acids, enzymes, monosaccharides, oligosaccharides, polysaccharides, sugars, etc.
Fig 1. Synthesis Route Design of Compound oxynitidine (Yang Shi et al. 2018)
Benzo-oxygen heterocyclic natural products have abundant sources, complex structures, huge numbers and obvious biological activities in the nature, since being discovered, they have become the focus researches of organic synthesis，and have got important applications in the field of medicine, pesticide and materials.
Sesquiterpenoid natural products play an important role in pesticide insecticides, insect antifeedants and anti-hypertension. However, there are many kinds of natural antifeedant agents, including terpenes, alkaloids, and glycosides and so on. Among them, the use of alkene antifeedant is the main natural antifeedant towel. So it is important for synthesis of bicyclic sesquiterpenes.
Daphnane diterpenoids usually embrace a 5/7/6-tricyclic ring system with poly-hydroxyl groups located at C3, C4, C5, C9, C13, C14, C20 and some special ones have a characteristic orthoester motif located at C9, C13, C14. The in-vitro and in-vivo experiments of these compounds have shown that they bear a wide range of biological activities including anti-HIV, anticancer, anti-leukemic, neurotrophic, pesticidal and cytotoxic effects.
Lepadins are a growing family of cis-decahydroquinoline alkaloids. Eight lepadin alkaloids have been isolated from several marine sources including the tunicate clavelina lepadiformis and its predator the flatworm prostheceraeus vittatus (lepadins A−C). It is important for synthesis of (-)-lepadins A-C.
BOC Sciences provides high-quality, low-cost, high-tech products to customers around the world. We has employed a dedicated staff of professional chemists to help you develop the most efficient process for synthesis of natural products. With diverse state-of-the-art technologies and approaches, clients’ synthetic route can be developed and optimized in the most cost effective way. In addition, various advanced techniques (NMR, LCMS, GCMS, HPLC, IR, and X-ray) are available in our laboratory to ensure your requirements can be met with high quality and timely.
What is total synthesis and semi-synthesis in natural product chemistry?
Total synthesis is the complete chemical construction of a natural product from simple, commercially available starting materials. Semi-synthesis modifies or derives natural products from naturally sourced compounds, combining isolation and chemical transformation steps.
What is the difference between synthesis and semi-synthesis?
Synthesis refers broadly to the chemical creation of a compound, either from simple starting materials (total synthesis) or by modifying existing molecules. Semi-synthesis specifically uses naturally occurring substances as intermediates, reducing the number of synthetic steps.
What is the semi-synthesis of natural products?
Semi-synthesis of natural products involves isolating a precursor molecule from natural sources—such as plants, microbes, or marine organisms—and chemically transforming it into a desired final product with improved properties or new functionalities.
What is total synthesis of natural products?
Total synthesis of natural products is the step-by-step chemical assembly of complex biomolecules entirely from simple precursors, often used to confirm molecular structures, create analogs, and produce compounds that are scarce in nature.
What natural product synthesis capabilities does BOC Sciences offer?
BOC Sciences provides both total synthesis and semi-synthesis services for a wide range of natural products, including alkaloids, terpenes, polyketides, and peptides. Our expertise covers route design, chiral control, scale-up, and comprehensive analytical characterization.
We offer semi-synthesis and total synthesis of natural products, delivering structurally authentic and high-purity compounds.
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