Liposomes can be surface-modified with a variety of molecules that carry out number of functions such as promoting the targeting of the vesicles to specific tissues, cell types and/or modulate, e.g., by PEGylation, their biodistribution and pharmacokinetic properties. Targeting, which represents a major issue to increase the specificity and efficiency of bioactive molecules (drugs, genes, etc.) delivery, involves, in most cases, the use of ligands that are recognized by receptors (over)expressed at the surface of target cells. These ligands are either relatively small molecules, such as folic acid, peptides or carbohydrate clusters which trigger receptor-mediated endocytosis, or proteins such as monoclonal antibodies and their fragments, that are directed against specific antigens.
Application of Liposome Bioconjugation
Probing protein activity, function and mechanism
Infection or pathogenesis control
Drug delivery and targeting
Prompt vaccines and immunotherapy
Anti-inflammatory strategies
Draft anti-inflammatory strategy
Benefit for medical transfer and locating
Explore the activity, function and mechanism of protein
Applied in study for cell
Our featured liposome bioconjugation targets
Antibody, biotin, protein, antigen or hapten-liposome conjugates
Peptide palmitic acid, palmitic acid and stearic acid modification
Oligo-cholesterol modification and oligo-cholesterol-PEG conjugates
BOC Sciences is able to provide high-quality and fast-delivering custom liposome bioconjugation service to support your drug development program. Through the method of covalently linkage, macromolecules or chemical compounds such as peptides, oligonucleotides, antibodies, oligosaccharides or drugs can be efficiently attached to the surface of liposomes or lipid emulsions. Relying on the state-of-the art chemical biology facilities, we are capable of offering multiple services on liposome bioconjugation in worldwide range.
Engineer targeted systems using BOC Sciences liposome bioconjugation
We engineer liposome bioconjugation with controlled composition, stability, and targeted delivery capabilities.
Spanedda, M. V., De Giorgi, M., Hassane, F. S., Schuber, F., Bourel-Bonnet, L., & Frisch, B. (2017). Coupling of ligands to the liposome surface by click chemistry. In Liposomes (pp. 93-106). Humana Press, New York, NY.
Riaz, M., Zhang, X., Lin, C., Wong, K., Chen, X., Zhang, G., ... & Yang, Z. (2018). Surface functionalization and targeting strategies of liposomes in solid tumor therapy: A review. International journal of molecular sciences, 19(1), 195.
