Liposome Bioconjugation

Liposomes can be surface-modified with a variety of molecules that carry out number of functions such as promoting the targeting of the vesicles to specific tissues, cell types and/or modulate, e.g., by PEGylation, their biodistribution and pharmacokinetic properties. Targeting, which represents a major issue to increase the specificity and efficiency of bioactive molecules (drugs, genes, etc.) delivery, involves, in most cases, the use of ligands that are recognized by receptors (over)expressed at the surface of target cells. These ligands are either relatively small molecules, such as folic acid, peptides or carbohydrate clusters which trigger receptor-mediated endocytosis, or proteins such as monoclonal antibodies and their fragments, that are directed against specific antigens.

Application of Liposome Bioconjugation

• Probing protein activity, function and mechanism
• Infection or pathogenesis control
• Drug delivery and targeting
• Prompt vaccines and immunotherapy
• Anti-inflammatory strategies
• Draft anti-inflammatory strategy
• Benefit for medical transfer and locating
• Explore the activity, function and mechanism of protein
• Applied in study for cell

Our featured liposome bioconjugation targets include, but not limited to

• Antibody, biotin, protein, antigen or hapten-liposome conjugates
• Peptide palmitic acid, palmitic acid and stearic acid modification
• Oligo-cholesterol modification and oligo-cholesterol-PEG conjugates
• Fluorescent dye labeled liposomes
• Stearyl oligo modification
• Phosphatidyle Glycerol (PG), Phosphatidyl Inositol (PI) and Phosphatidyle Ethanolamine (PE) modification

Our featured liposome derivatives for bioconjugation:

• NHS ester modified Palmitate
• Biotinylated Liposome
• Glutaraldehyde-Activated Liposome
• N-Succinimidyl 3-(2-pyridyldithio) propionate (SPDP)-Activated Liposome
• Sulfosuccinimidyl-4-(p-maleimidophenyl) butyrate (SMBP)-Activated Liposome
• Succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC)-Activated Liposome
• SIAB-Activated Liposome

Why Choose BOC Sciences?

BOC Sciences is able to provide high-quality and fast-delivering custom liposome bioconjugation service to support your drug development program. Through the method of covalently linkage, macromolecules or chemical compounds such as peptides, oligonucleotides, antibodies, oligosaccharides or drugs can be efficiently attached to the surface of liposomes or lipid emulsions. Relying on the state-of-the art chemical biology facilities, we are capable of offering multiple services on liposome bioconjugation in worldwide range.

References:

1. Spanedda, M. V., De Giorgi, M., Hassane, F. S., Schuber, F., Bourel-Bonnet, L., & Frisch, B. (2017). Coupling of ligands to the liposome surface by click chemistry. In Liposomes (pp. 93-106). Humana Press, New York, NY.
2. Riaz, M., Zhang, X., Lin, C., Wong, K., Chen, X., Zhang, G., ... & Yang, Z. (2018). Surface functionalization and targeting strategies of liposomes in solid tumor therapy: A review. International journal of molecular sciences, 19(1), 195.