Nucleosides & Nucleotides

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Nucleosides & Nucleotides

Natural nucleobases, which include adenine (A), guanine (G), cytosine (C), thymine (T) and uracil (U), are the basic building blocks of nucleic acids. Nucleosides consist of a nucleobase and a sugar ring (20-deoxyribose for DNA and ribose for RNA). Nucleotides are composed of a nucleoside, and at least one phosphate group. Chemotherapeutic nucleoside, nucleotide, and base analogs, herein referred to as “nucleoside analogs”, are antimetabolites. Nucleoside analogs have been a cornerstone of anticancer and antiviral chemotherapy for decades. Nucleoside and nucleotide derivatives can inhibit key cellular enzymes, providing a secondary mode of action that inhibits cell growth.

Nucleosides & Nucleotides

Below is a list of our nucleosides & nucleotides analogs (include but not limited to the following):

Anticancer nucleoside analogs

Cytotoxic nucleoside analogues and nucleosidases were the first chemotherapeutic drugs to be used to treat cancer. These compounds have been developed to include a variety of purine and pyrimidine nucleoside derivatives, which are active in solid tumors and hematological malignancies. As anti-metabolic drugs, these drugs compete with physiological nucleosides and interact with a large number of intracellular targets to induce cytotoxicity.

7-deazapurine (pyrrolo [2, 3-d] pyrimidine) nucleosides display a variety of biological effects, such as antiviral and cytotoxicity against neoplastic cell lines. Thanks to their resemblance to natural purine nucleosides, 7-deazapurine nucleosides can interfere with enzymes of nucleosides, 7-deazapurine nucleosides can interfere with enzymes of nucleoside metabolism, kinases, RNA and DNA synthesis and so on.

Nucleosides and 2’-deoxyribonucleoside triphosphates (dNTPs) bearing phenothiazine (PT) attached to a nucleobase (cytosine or 7-deazaadenine) either directly or through an acetylene linker were prepared through Suzuki or Sonogashira cross-coupling and triphosphorylation. The syntheses started from commercial 2'-deoxy-5-iodocytidine or from well-known 2′-deoxy-7-iodo-7-deazaadenosine, which were triphosphorylated to the corresponding dNTPs.

Why Choose BOC Sciences?

BOC Sciences provides high-quality, low-cost, high-tech products to customers around the world. We has employed a dedicated staff of professional chemists to help you develop the most efficient process for synthesis of nucleosides & nucleotides analogs. With diverse state-of-the-art technologies and approaches, clients’ synthetic route can be developed and optimized in the most cost effective way. At BOC Sciences, our customers will be resourced with various kinds of synthetic and analytical instrumentations. Our experts will work with you to optimize the synthetic route and approaches. Additionally, according to your needs and the properties of chemical substances, a wide range of custom services are available in our laboratory.

Reference

  1. Robertson, M. J., Tirado-Rives, J., & Jorgensen, W. L. (2017). Improved treatment of nucleosides and nucleotides in the OPLS-AA force field. Chemical physics letters683, 276-280.
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