Nucleosides & Nucleotides

Nucleosides & Nucleotides

BOC Sciences provides efficient, flexible, and high-quality one-stop solution for new drug development, from APIs to formulations. Our synthesis services, aligning with standards to ensure product quality.

Nucleobases including adenine (A), guanine (G), cytosine (C), thymine (T) and uracil (U), are the basic building blocks of nucleic acids. Nucleosides consist of a nucleobase and a sugar ring (20-deoxyribose for DNA and ribose for RNA). Nucleotides are composed of a nucleoside, and at least one phosphate group. Being referred to as the nucleoside analogs, chemotherapeutic nucleoside, nucleotide, and base analogs are antimetabolites. Nucleoside analogs have been a cornerstone for anticancer and antiviral chemotherapy for decades. Nucleoside and nucleotide derivatives can inhibit key cellular enzymes, providing a secondary mode of action that inhibits cell growth.

Nucleosides & Nucleotides

Below is a list of our nucleosides & nucleotides analogs (include but not limited to the following):

Anticancer nucleoside analogs

Cytotoxic nucleoside analogues and nucleosidases were the first chemotherapeutic drugs to be used to treat cancer. These compounds have been developed to include a variety of pyrimidine nucleoside derivatives, which are active in solid tumors and hematological malignancies. The anti-metabolic drugs compete with physiological nucleosides and interact with a large number of intracellular targets to induce cytotoxicity.

7-deazapurine (pyrrolo [2, 3-d] pyrimidine) nucleosides display a variety of biological effects, such as antiviral and cytotoxicity against neoplastic cell lines. Thanks to their resemblance to natural purine nucleosides, 7-deazapurine nucleosides can interfere with enzymes of nucleosides, 7-deazapurine nucleosides can interfere with enzymes of nucleoside metabolism, kinases, RNA and DNA synthesis and so on.

Nucleosides and 2’-deoxyribonucleoside triphosphates (dNTPs) bearing phenothiazine (PT) attached to a nucleobase (cytosine or 7-deazaadenine) either directly or through an acetylene linker were prepared through Suzuki or Sonogashira cross-coupling and triphosphorylation. The syntheses started from commercial 2'-deoxy-5-iodocytidine or from well-known 2′-deoxy-7-iodo-7-deazaadenosine, which were triphosphorylated to the corresponding dNTPs.

Our professional instruments include but not limited to the following:

Nucleosides & Nucleotides

Why Choose BOC Sciences?

BOC Sciences provides high-quality and low-cost products to customers around the world. Our dedicated chemists help develop the most efficient process to synthesize nucleosides & nucleotides analogs using diverse state of the art technologies and approaches. We will work with you to optimize the synthetic route and approaches. Customer service is always ready for you at any time.

Reference

  1. Robertson, M. J., Tirado-Rives, J., & Jorgensen, W. L. (2017). Improved treatment of nucleosides and nucleotides in the OPLS-AA force field. Chemical physics letters, 683, 276-280.
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