High-throughput Screening

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High-throughput Screening

BOC Sciences provides high-quality, customized, high-throughput drug screening services based on experimental methods at the molecular and cellular levels. To ensure the reliability of the service, we are equipped with a high capacity chemical library, automated operating system, high sensitivity detection system, efficient data processing system and highly specific drug screening model. In the process of high throughput screening, BOC Sciences can carry out quality control, information tracking and data storage for all key steps according to customer requirements and industry standards, to ensure the safety of all outputs.

High-throughput screening technology is a method for screening candidate drugs that interact with targets from a large number of drug samples by using microplates containing molecules (such as enzymes and receptors) and cells as carriers. Candidate drugs are screened for the effect of the sample on the biological activity of the target or the overall cells. In the process of high-throughput screening, multiple disciplines are closely combined, such as pharmaceutical chemistry, molecular biology, cell biology, mathematics, microbiology and computer science. With the rapid development of high-throughput screening technology, it has become an important way to discover new drugs.

high-throughput-drug-screening

Below is a list of our High-throughput screening process:

Preparation of samples and composite libraries

Screening facilities usually store their composite library collections in so-called “inventory disks”. The chopping board was not used directly in the experiment. Instead, when necessary, the compound from the storage plate is “copied” to the analytical plate through the liquid transfer station.

The establishment of strict analysis methods and effective quality control methods is the main problem in the establishment of automatic screening. The clearer the difference between the negative control and the positive control, the greater the likelihood of obtaining high-quality data.

The scope of robot platform is to manage multiple plates at the same time, which greatly speeds up the speed of data acquisition. Robot platforms for high-throughput screening range from simple automated liquid processing machines to multidimensional workstations that perform a variety of functions.

Data management is a key point in automated high-throughput screening because of the large number of compounds tested, the diversity of chemical libraries, and the need to correlate and compare the results of different screening activities.

We make use of our rich experience in pharmaceutical chemistry to promote the new drug process to enter the identification of candidates and new drug clinical research earlier, and effectively help our customers control the cost of new drug development.

Our Methods

  • Optical detection technology
  • Radioactive detection technology
  • Fluorescence detection technology
  • Multifunctional microplate detection system

Our Advantages

  • Large high-throughput screening compound library
  • High specificity
  • Continuous update of compound library

BOC Sciences provides a wide range of expertise from an industrial and academic background. This means that we can provide a wide range of screens on multiple platforms and can provide technical and scientific advice for the development and execution of your analysis from the initial stages of development to completion and data analysis.

References

  1. Bajorath, J. (2002). Integration of virtual and high-throughput screening. Nature Reviews Drug Discovery, 1(11), 882.
  2. Gao, H., Korn, J. M., Ferretti, S., Monahan, J. E., Wang, Y., Singh, M., ... & Balbin, O. A. (2015). High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response. Nature medicine, 21(11), 1318.
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