Halogenation

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Halogenation

Halogenation represents a chemical reaction that is involved in the process of introducing halogen atoms to organic compound molecules. Halohydrocarbons, which has a widely application in various fields including food production, heavy industry, consume goods manufacturing and the pharmaceutical industry, may be the featured application of halogenation. By introducing halogen atoms into the molecular structure of certain compounds, the physicochemical properties and even the pharmacological activity can be dramatically changed or enhanced.

Below is a list of our Halogenation Services (include but not limited to the following):

Fluorination

In general, fluorination represents the reaction between the fluorine and saturated or unsaturated organic compounds. Due to the high thermal stability and non-toxic properties of organic fluorides, the fluorination reaction is getting more and more attention from numerous chemists and pharmaceutical experts.

Chlorination refers to the reaction of introducing chlorine into the structure of a drug candidate and generally composed by displacement chlorination, addition chlorination, and oxidative chlorination. Moreover, the reaction between an inorganic element or compound and chlorine can be also called as chlorination. Chlorination has a wide application in both food industry and pharmaceutical manufacturing.

Bromination is the reaction of hydrogen in an organic compound molecule replaced by bromine to form a bromine-containing compound. As compared with chlorination, bromination is more selective when reacting with the saturated hydrocarbons, and aromatic compounds. Brominated compounds can be used in chemical synthesis, medicine and other fields.

Similar to the bromination, the basic principle for iodination is that hydrogen in an organic compound molecule is replaced by iodine. As the most inactive ones in halogens, the hydrogen in alkanes is not easy to be replaced by iodine to form the iodoalkane unless in the presence of iodinating reagent tert-butyroyl iodide [(CH3)3COI]. For the iodination of aromatics, Tetramethylammonium Dichloroiodate (TMADCI) is indispensable to induce the reaction generation.

Why Choose BOC Sciences?

Scientists from BOC Sciences are able to handle a large quantities of chlorine, bromine, iodine, and other halogenating agents effectively and safely. Using our unique range of equipment, we can work with our customers to develop efficient halogenation processes no matter as a stand-alone project or as the part of a larger synthetic plan. More importantly, we have great capability to evaluate and execute your halogenation requirement safely. We offer complete, timely, and cost-effective NMR testing services to meet the requirements and promote your project program. More importantly, the routine analysis at our laboratory is ensured turned around within 24 hours. Please contact us for more detailed halogenation information.

Reference

  1. Weiss, H. M., & Ganz, L. (1999). A safe simple halogenation experiment. Journal of chemical education76(4), 534.
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