Peptide Bioconjugation

Peptide Bioconjugation

Bioconjugation technology has caused the birth of billion-dollar industries serving research, diagnostics, and therapeutic markets. A significant portion of all biological assays, including clinical testing, is now done using unique bioconjugates that have the ability to interact with particular analytes in solutions, cells, or tissues. Crosslinking and modifying agents can be applied to alter the native state and function of peptides and proteins. Through careful modification or conjugation strategies, the structure and function of peptides and proteins can be investigated, active site conformation discovered, or receptor-ligand interactions revealed.

Application of Peptide Bioconjugation

Modification with peptides with certain molecules such as oligonucleotides, fluorescent dyes, chromogenic enzyme substrates, drugs, toxins or carrier proteins is supposed to be an effective improvement strategy. Taking the peptide-drug conjugates for example, such a transformation system was thought to be able to bypass the identification of macrophage crossing biological obstacle and accrete the entrance of the target cell. Organometal-peptide bioconjugates have a variety of applications in biomedical studies, such as anti-proliferative and anti-bacterial activity, as well as to aid the elucidation of the mode of action of the conjugated metal complexes. Besides, the incorporation of metals may bring about a new and unprecedented activity or selectivity, or it may offer additional, metal-specific means of detection, such as Atomic Absorption Spectroscopy (AAS).

Below is a list of our Peptide Bioconjugation Services (include but not limited to the following):

  • Peptide-protein/antibody conjugation
  • Dendritic Peptide
  • Peptide-small molecule conjugation
  • Peptide-siRNA conjugates
  • PEGylation
  • Surface immobilization
  • Synthetic polymer modification
  • Oligo peptide conjugates
  • Peptide-drug conjugates
  • Peptide-DNA conjugates
  • Peptide-RNA conjugates
  • Peptide-siRNA conjugates
  • Other oligo peptide conjugates
  • Liposome conjugation

Why Choose BOC Sciences?

BOC Sciences has the abilities to develop a reliable procedure for the peptide bioconjugation, we can provide global customers with peptide bioconjugation product based on our excellent technology. We have extensively developed peptide bioconjugate strategy and are the choice to satisfy your peptide bioconjugation requirements, providing a confidential and efficient service at competitive prices.

  • Providing extensive length for peptide and suitable molecular size and purity
  • Offering statistical reports for every signal peptide
  • Determining synthesized sequence during short time
  • Robust peptide library and database

References:

  1. Jones, M. W., Mantovani, G., Blindauer, C. A., Ryan, S. M., Wang, X., Brayden, D. J., & Haddleton, D. M. (2012). Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts. Journal of the American Chemical Society, 134(17), 7406-7413.
  2. El-Mahdi, O., & Melnyk, O. (2013). α-oxo aldehyde or glyoxylyl group chemistry in peptide bioconjugation. Bioconjugate chemistry, 24(5), 735-765.
  3. Melnyk, O., Ollivier, N., Besret, S., & Melnyk, P. (2014). Phenylthiocarbamate or N-carbothiophenyl group chemistry in peptide synthesis and bioconjugation. Bioconjugate chemistry, 25(4), 629-639.
Quote Request
Verification code