Metabolites Synthesis

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Metabolites Synthesis

Metabolites of pharmaceutical compounds are pivotal to comprehending drug metabolism, potential drug interactions, and human drug metabolizing enzymes. Primary metabolites are synthesized by the cell because they are critical for biological growth like alcohols and vitamins. Secondary metabolites are the compounds produced by an organism. They are not essential for primary metabolic processes, although they can have important ecologic and other functions such as pesticides and drugs.

Metabolites synthesis is vital to advances in science and medicine today when investigators look for a deeper understanding of the chemical processes of cells or drug metabolism and apply those insights to new approaches to identifying diseases and discovering new treatments.

Application of Metabolites Synthesis

By understanding how small molecules can be transformed as part of biochemical processes, we can better correlate the impact of those treatment or drug on cell health. The synthesis and purification of considerable amounts of the metabolites provides reliable conclusions regarding the cardiotoxicity of drug metabolites and then pharmacological prevention or treatment of the disease side effects. Also, the metabolites, which are resistant to insect and microbial infections, help us adapt to the environment. Most of the known secondary metabolites are difficult and infeasible to obtain due to their unexplored chemicals synthesis. In that case, we use an alternative biotechnology way for the production of such kind of metabolites like sugars, fatty acids, alkaloids, glycosides, flavonoids, volatile oils, tannins and resins etc. Despite the limited supply of metabolites, we would pursue different strategies to elicit the desirable product in feasible quantity and higher purity.

Our Advantages

  • Equipped with a wide range of technologies, providing metabolites or bioactive compounds, phyto-pharmaceuticals occurring in plants cells.
  • With the help of professional experts from different area, like Plant science, Pharmacognosy, Microbiology, Phyto-chemistry, Biochemistry, Molecular biology.
  • In quantities of several milligrams up to 100 grams.
  • Additional analyses, such as stability determination, impurity analysis, and residual solvents etc.
  • With diverse state-of-the-art technologies and approaches.
  • Quality assurance: HPLC chromatogram and Mass spec analysis.
  • Overnight shipping with suitable packs.

Reference

  1. Varela, C. L., Amaral, C., da Silva, E. T., Lopes, A., Correia-da-Silva, G., Carvalho, R. A., ... & Teixeira, N. (2014). Exemestane metabolites: synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line. European journal of medicinal chemistry, 87, 336-345.
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