Immunotoxicity testing is a critical assessment for determining how a compound or biologic influences the immune system. It can detect whether the immune system is suppressed or overactivated using assays such as lymphocyte proliferation, NK cell activity, cytokine release, and phagocytosis. Accurate assessment of immune responses is essential for guiding compound optimization, minimizing risk, and ensuring effective early-stage R&D decision-making. BOC Sciences offers comprehensive immunotoxicity services, spanning in vitro functional assays, in vivo systemic evaluations, and high-throughput screening for small molecules, biologics, nanomaterials, and other sample types. Leveraging integrated platforms, robust data analysis, and scalable throughput, BOC Sciences supports pharmaceutical companies, biotech innovators, CROs, and academic researchers with reliable, mechanistic insights to accelerate discovery and enhance immune safety profiling.
We provide early-stage immunotoxicity screening to rapidly assess potential immune risks of compounds or biologics. At BOC Sciences, we utilize lymphocyte proliferation, NK cell activity, cytokine release, and phagocytosis assays, helping you identify immunosuppressive or activating effects efficiently and cost-effectively.
Our immune mechanism analysis explores how compounds interact with the immune system. Using T cell-antigen presenting co-cultures, signaling pathway assays, and cytokine profiling, BOC Sciences delivers insights into immune pathways, targets, and functional modulation to guide rational design and optimization.
We offer comprehensive in vivo immune evaluation, including TDAR, lymphoid organ analysis, immunophenotyping, and delayed-type hypersensitivity assays. At BOC Sciences, these studies quantify systemic immune impact, providing a clear profile of functional alterations and supporting informed R&D decision-making.
Our high-throughput immunotoxicity platform rapidly screens large compound libraries for immune risks. BOC Sciences combines automated assays, multiplex cytokine analysis, and functional cell testing to efficiently prioritize safe candidates, significantly accelerating early discovery and optimizing compound selection.
Our tailored immunoassay services cover multiple sample types and are designed to accelerate your project timelines.
This assay evaluates T and B cell proliferation using 3H-thymidine incorporation or CFSE staining with flow cytometry. At BOC Sciences, this method identifies immunosuppressive or activating effects, providing reliable early-stage functional data to guide candidate selection and immune safety assessment.
The NK cell assay measures NK cell cytotoxic activity through flow cytometry or 51Cr release. BOC Sciences provides precise evaluation of innate immune cytotoxicity, enabling clients to detect functional alterations and potential immune modulation caused by compounds efficiently and reproducibly.
The phagocytosis assay assesses macrophage and neutrophil engulfment and oxidative burst using fluorescently labeled particles and flow cytometry. At BOC Sciences, it delivers accurate quantification of innate immune function, supporting mechanistic studies and evaluation of compound-induced immune modulation.
Cytokine release assays quantify immune mediator production, including IL-2, IL-6, TNF-α, and IFN-γ, using ELISA or Luminex multiplex platforms. BOC Sciences provides comprehensive cytokine profiling to support mechanistic analysis, immune modulation assessment, and early immunotoxicity screening efficiently.
Cytotoxicity assays assess immune cell viability and apoptosis using MTT, LDH release, or Annexin V/PI staining. At BOC Sciences, this method delivers precise evaluation of cellular toxicity, enabling clients to identify potential immunosuppressive effects and guide safe compound selection during early-stage development.
The antigen presentation assay evaluates dendritic cell or macrophage function through T cell co-culture and flow cytometry. BOC Sciences provides mechanistic insight into adaptive immune activation, allowing clients to assess how compounds impact antigen processing, presentation, and T cell stimulation efficiently.
TDAR measures IgM and IgG antibody production following SRBC or KLH immunization in mice or rats. At BOC Sciences, this in vivo assay quantifies systemic humoral immune function, providing essential data to detect potential immunotoxicity and support preclinical evaluation of immune safety.
Lymphoid organ analysis examines spleen, lymph node, and thymus weight and histology using tissue sectioning and H&E staining. BOC Sciences provides structural and functional evaluation of primary and secondary lymphoid organs, offering critical information on immune system integrity under compound exposure.
Immunophenotyping analyzes T, B, and NK cell proportions and activation status using flow cytometry or immunofluorescence. At BOC Sciences, this method delivers detailed immune cell profiles, enabling clients to assess functional immune modulation and identify potential immune-toxic effects comprehensively.
Hematopoietic assessment evaluates bone marrow cytology and immune-related parameters through smears and cell counting. BOC Sciences quantifies the integrity of hematopoietic and immune systems, providing key data to support systemic immunotoxicity evaluation and informed decision-making in compound development.
The DTH assay measures T cell-mediated skin responses by evaluating skin thickness changes. At BOC Sciences, this method provides sensitive assessment of cellular immune function, allowing clients to detect immune modulation and potential adverse immune-toxic effects efficiently in preclinical studies.
This assay evaluates IgE levels and tissue inflammation in specific allergy animal models. BOC Sciences assesses immune activation and hypersensitivity potential, offering valuable insights into compound-induced immune responses and early identification of immunotoxicity risks during preclinical development.
Our immunotoxicity studies services support a broad range of sample types to evaluate immune system interactions, immune modulation, and systemic immune responses.
Provide details of your project or samples, and get prompt expert advice along with tailored immunoassay testing options.
Clients share sample details and testing objectives. Our specialists clarify goals and design a tailored immune toxicity testing plan.
Samples are processed and prepared. Customized experimental methods and assays are selected to ensure accurate and reproducible immune toxicity analysis.
Our team conducts immune toxicity experiments, monitors responses, and collects high-quality data for comprehensive and reliable evaluation.
Results are analyzed and interpreted by experts. A detailed report is prepared and delivered, summarizing key findings and insights.
We provide tailored immunotoxicity testing for emerging biologics and therapeutic proteins, including immune cell profiling, cytokine analysis, and in vivo models. Our solutions empower biotech innovators to optimize candidate safety and streamline early-stage R&D efficiently.
BOC Sciences delivers comprehensive immunotoxicity assessment for small molecules and advanced therapeutics. Services include immune function assays, hypersensitivity evaluation, and mechanistic studies, enabling pharmaceutical companies to refine drug design and support robust preclinical pipelines.
We offer flexible immunotoxicity testing packages for CROs, covering assay design, immunophenotyping, and customized reporting. Our service allows CROs to expand offerings, meet diverse client requirements, and maintain high-quality standards across multiple projects.
Our tailored immunotoxicity solutions support academic labs with mechanistic and functional immune studies, including in vitro immune cell assays and ex vivo analyses. Researchers benefit from precise data generation to advance immunology and drug discovery programs efficiently.
Engage BOC Sciences for comprehensive immune profiling services. We deliver detailed, reproducible data on cellular and humoral responses, accelerating your research timeline with expert support.
We offer integrated in vitro and in vivo assays enabling multi-dimensional immunotoxicity profiling across diverse biological models efficiently.
Our expert team combines statistical analysis with mechanistic insights, ensuring meaningful interpretation of complex immunological response patterns.
We provide flexible testing throughput, from pilot studies to large-scale projects, supporting varied research timelines and experimental demands.
Our reports are structured for clarity and reproducibility, offering comprehensive datasets suitable for strategic decision-making and portfolio development.
Client Needs: A biotechnology company developing a novel monoclonal antibody sought a comprehensive immunotoxicity assessment to understand potential systemic immune perturbations and support candidate selection.
Challenges: The client observed atypical cytokine responses and unpredictable T-cell activation in preliminary in vitro experiments. Conventional immunophenotyping methods were insufficient to detect subtle immune imbalances, limiting confidence in early candidate selection.
Solution: BOC Sciences implemented a multi-tiered immunotoxicity testing strategy, integrating flow cytometry for lymphocyte subset analysis, multiplex cytokine profiling via ELISA, and in vivo functional immune assays. Advanced statistical modeling ensured detection of minor perturbations, while cross-species comparisons provided mechanistic insight.
Outcome: Delivered precise immunotoxicity maps, highlighting transient cytokine shifts and selective T-cell activation patterns. The data guided dosing optimization and molecular design, providing actionable insights for subsequent preclinical studies.
Client Needs: A pharmaceutical company developing small-molecule immunomodulators required early-stage immunotoxicity evaluation to prevent adverse immune reactions and guide lead optimization.
Challenges: The client observed low-level but variable off-target immune activity, inconsistent cytokine induction, and minor histopathological changes that conventional assays could not reliably detect, complicating candidate prioritization.
Solution: BOC Sciences implemented an integrated testing workflow combining in vitro human immune cell assays, cytokine release panels, and targeted organ-specific immune histopathology. Dose-response analysis and time-course sampling provided detailed insight into transient versus persistent immune effects.
Outcome: Identified subtle immunotoxicity signatures, enabling chemical scaffold refinement and precise adjustment of therapeutic windows. The client was able to prioritize candidates with optimal immune safety profiles.
Client Needs: A vaccine developer sought to evaluate potential immune-toxic effects of a novel adjuvant designed to enhance humoral and cellular responses without triggering systemic immune dysregulation.
Challenges: The client observed inconsistent inflammatory biomarker patterns in preclinical models, and traditional assays lacked sensitivity to detect low-level immune perturbations across multiple organs, limiting safety assessment.
Solution: BOC Sciences applied a comprehensive immunotoxicity testing approach, combining multiplex cytokine profiling, flow cytometry for immune cell subset dynamics, and organ-specific histopathological evaluation. Multi-timepoint monitoring and advanced bioinformatics ensured reproducible, high-resolution immune response mapping.
Outcome: Identified specific immune cell activation trends and low-grade organ-specific inflammatory signals, informing adjuvant formulation and dose optimization. The results supported confident progression of next-generation vaccines with improved immune safety.
Immunotoxicity testing evaluates the potential adverse effects of compounds or biologics on the immune system. By using in vitro or in vivo models, researchers can analyze how a candidate molecule affects immune cell function, cytokine production, and immune regulation. Such assessments provide critical data to optimize molecular design. BOC Sciences offers extensive experience in immune cell functional analysis and quantitative assessment, ensuring high-quality support for your research.
Common models include lymphocyte proliferation assays, NK cell activity tests, macrophage phagocytosis assays, and cytokine profiling. Integrated in vitro co-culture systems can also simulate complex immune environments, providing precise insights during early compound screening. BOC Sciences can provide customizable immune function testing platforms tailored to specific research needs.
Systematic assessment of key immune indicators, such as T/B cell ratios, abnormal cytokine secretion, or suppressed immune cell function, can help identify potential immune-toxic risks. Dose-dependent analysis further clarifies the relationship between compound concentration and immune response, supporting structure optimization or selection of safer candidates.
During early-stage development, immunotoxicity testing helps screen out molecules that may significantly suppress or overstimulate the immune system. In later stages, detailed evaluations of immune function impacts and mechanisms provide deeper insight. Comprehensive immunotoxicity analysis reduces development risks and enhances the scientific basis for subsequent studies.
Key factors include the scientific rigor of study design, comprehensiveness of measured endpoints, and expertise in data interpretation. High reproducibility and precision are critical for informed decision-making. BOC Sciences offers a complete immunology testing workflow with experienced scientific teams, from study design to data analysis, helping clients make reliable, evidence-based decisions.
The immunotoxicity testing services provided by BOC Sciences offered thorough and actionable insights into our compound's immune profile. The detailed mechanistic analysis and robust assay design allowed us to better understand potential immune interactions, significantly enhancing our preclinical strategy.
— Dr. K., Senior Scientist, Innovative Biopharma Startup
BOC Sciences' immunotoxicity testing consistently produces comprehensive and reliable data. Their systematic evaluation of immune endpoints, coupled with meticulous documentation, has strengthened our confidence in project decision-making and supported internal risk assessments.
— Dr. M., Head of Research, Specialty Biotech Firm
We found BOC Sciences' team highly knowledgeable and responsive throughout the immunotoxicity testing process. Their in-depth analysis of cytokine responses and immune cell interactions provided us with actionable data, helping to optimize our candidate selection strategy.
— Dr. J., Principal Investigator, Mid-sized Pharmaceutical Company
The immunotoxicity assessments conducted by BOC Sciences delivered consistent and reproducible results across multiple studies. Their methodical approach to assay validation and immune profiling has been instrumental in supporting our internal research priorities.
— Dr. S., Director of Preclinical Research, Emerging Biotech Enterprise
