Lipoproteins bind to proteins to form lipid-protein complexes. Lipoproteins are mainly bound through hydrophobic interactions between their nonpolar lipid component and their nonpolar protein component, rather than via covalent bonds. Chemical composition, centrifugal sedimentation behavior, and solubility are typical characteristics of lipoproteins. Essentially, it transports and metabolizes lipids within the body.
Fig 1. Structures of LDL and HDL.
Lipoproteins are responsible for transporting ingested lipids from sites such as the intestines and liver to various cells in the body.
Lipoproteins collect lipids from tissues and organs in the body and transport them back to the liver for metabolism and breakdown.
Lipoproteins help stabilize the level of lipids in the blood and maintain energy balance throughout the body.
BOC Sciences offers custom synthesis of lipoproteins in the following.
First, phospholipid monolayers and protein components are synthesized. Then, the lipids are reacted with carrier proteins to form lipoproteins through chemical synthesis methods. Finally, the synthesized lipoproteins are then structurally verified by mass spectrometry, NMR and other techniques.
BOC Sciences offers a comprehensive suite of lipoprotein synthesis services, designed to meet the precise needs of researchers and industry professionals. Our advantages lie in the combination of cutting-edge technology, expert knowledge, and rigorous quality control measures, ensuring that every custom lipoprotein product meets high standards of purity, stability, and functionality.
1. Customization and Structural Flexibility
We provide fully customizable lipoprotein synthesis, allowing clients to select specific lipid-to-protein ratios, particle sizes, and functional modifications. This flexibility enables the creation of tailored lipoproteins suitable for diverse applications, including biochemical research, drug delivery, and structural biology studies.
2. Advanced Analytical Verification
All synthesized lipoproteins undergo thorough structural and functional verification using advanced analytical techniques such as mass spectrometry, nuclear magnetic resonance (NMR), and chromatographic profiling. This ensures accurate composition, structural integrity, and reproducibility for downstream experimental applications.
3. Expertise in Functional Modifications
Our team specializes in post-synthetic modifications such as phosphorylation, glycosylation, and acetylation. These modifications can enhance lipoprotein stability, bioactivity, and interaction with cellular components, supporting research that requires precise control over functional properties.
4. High Purity and Consistency
BOC Sciences applies rigorous purification and quality assurance protocols to remove residual contaminants and maintain batch-to-batch consistency. High-purity lipoproteins facilitate reliable experimental outcomes and reduce variability in complex biological assays.
5. Integrated Research Support
Beyond synthesis, we provide guidance on experimental design, functional assays, and storage recommendations. This integrated support helps researchers optimize their use of lipoproteins in mechanistic studies, lipid metabolism research, and drug delivery investigations.
6. Scalability and Timely Delivery
We can accommodate small-scale research needs as well as large-scale production demands. Efficient workflow management ensures timely delivery without compromising quality, enabling researchers to meet project deadlines and accelerate scientific discovery.
Through these advantages, BOC Sciences empowers scientists and developers to access high-quality, functional lipoproteins tailored to their specific research objectives, ensuring reproducibility, reliability, and innovation in lipid-related studies.
BOC Sciences offers lipoprotein modification services, which include chemical modifications or structural changes to affect the function, stability of lipoproteins.
BOC Sciences offers services to analyze lipoproteins for information on their composition, structure and function. Lipoprotein analysis includes quantitative and qualitative analysis of protein fractions, analysis of lipid fractions, and determination of the molecular weight of lipoproteins.
The regulation of lipoprotein synthesis can be realized through the action of transcription factors. Examples include the liver X receptor (LXR) and nuclear factor E2-like transcription factor 2 (Nrf2).
After lipoprotein synthesis, protein components undergo multiple post-translational modification processes that can affect lipoprotein stability, structure, and function.
Multiple quality control mechanisms also exist within the cell to monitor and regulate lipoprotein synthesis and folding processes. These mechanisms can detect the proper folding and assembly of proteins and contribute to the degradation of abnormal proteins.
What is lipoprotein synthesis?
Lipoprotein synthesis is the biological process of assembling lipid–protein complexes that transport hydrophobic molecules such as cholesterol, triglycerides, and phospholipids through aqueous environments. It involves coordinated lipid incorporation and apolipoprotein association to form functional particles.
What is the main function of lipoproteins?
Lipoproteins are responsible for the transport and distribution of lipids in biological systems. They play a key role in energy supply, membrane structure maintenance, and the regulation of lipid metabolism.
What are the main types of lipoproteins?
Major classes include chylomicrons, very-low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL), each differing in lipid-to-protein ratio, size, and metabolic role.
What factors influence lipoprotein composition in research models?
Lipoprotein structure and composition can be influenced by lipid source, apolipoprotein profile, synthesis conditions, and post-synthetic modifications, all of which are important considerations in experimental design.
What lipoprotein synthesis capabilities does BOC Sciences provide?
BOC Sciences offers custom synthesis of lipoproteins with controlled composition, particle size, and functional modifications. Our capabilities support biochemical studies, structural analysis, and targeted delivery research across a variety of scientific applications.
We produce lipoproteins with controlled composition, high stability, and consistent performance, supporting studies in lipid metabolism and related areas.
Submit your inquiry to request a custom solution.
