Activity-based Libraries

Activity-based Libraries

In general, screening libraries contain amounts of compounds for the demands of academia and industry, which is inconvenient for researchers to study in the specific areas. Activity-based libraries are designed for researchers with the classification of compounds according to their potential application in different fields of drug discovery, which use a combination of validated descriptors and compound properties.

BOC Sciences provides customers with several categories of activity-based libraries (include but not limited to the following):

Anti-inflammatory libraries

Anti-inflammatory is to reduce inflammation by treatment or medicine. Anti-inflammatory drugs relieve pain through reducing inflammation, which is different from opioids that affect the central nervous system for pain reduction and make about 50% of analgesics. There are mainly two kinds of anti-inflammatory drugs used in clinical practice: non-steroidal anti-inflammatory drugs and steroidal anti-inflammatory drugs.

Anti-cancer is to treat malignancies or cancerous growths by using anti-cancer drugs or combination of drugs and other treatments such as radiation therapy and surgery. In 2003, a new technique was developed to search for effective anti-cancer drugs. The researchers selected more than 23000 compounds through screening techniques to kill cancer cells while keeping healthy cells free from harm. The system identified 9 compounds, including a previously unknown anti-cancer drug, which was an important factor for fighting cancer.

Antibiotics, also known as antibacterials, are antibacterial drugs used to treat and prevent bacterial infections by killing or inhibiting the growth of bacteria. A limited number of antibiotics also have antigenic activity. Antibiotics are ineffective against viruses such as colds or influenza. Drugs that suppress viruses are called antiviral drugs, not antibiotics. In modern society, most antibacterials are semisynthetic modifications of natural compound.

Antiprotozoal drug is a class of pharmaceuticals using to treat protozoan infection. The antiprotozoal drugs share the different mechanisms in diverse cases. For example, the aminoglycoside antiprotozoal for treating leishmaniasis is deemed to inhibit protein synthesis while eflornithine, a drug used for treating trypanosomiasis, inhibits ornithine decarboxylase.

Antituberculosis drugs for treating diseases caused by Mycobacterium genus, including tuberculosis and leprosy, have affected mankind since ancient times. Combination chemotherapy is critical for killing heterogeneous bacterial cells and preventing resistance under different conditions within the host.

Why Choose BOC Sciences?

At BOC Sciences, our customers will be resourced with various kinds of synthetic and analytical instrumentations. Activity-based libraries at BOC Sciences contain diverse biological and pharmacological compounds to be used as high content of screening materials. A complete report or certificate of each compound chemical structure is also provided to ensure the quality.


  1. Funeriu, D. P., Eppinger, J., Denizot, L., Miyake, M., & Miyake, J. (2005). Enzyme family–specific and activity-based screening of chemical libraries using enzyme microarrays. Nature biotechnology, 23(5), 622.
  2. Speers, A. E., & Cravatt, B. F. (2004). Chemical strategies for activity‐based proteomics. ChemBioChem, 5(1), 41-47.
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