Hygroscopicity Testing

Hygroscopicity Testing

Hygroscopicity of a material can be regarded as a physicochemical property that represents the ability of absorbing moisture from the surrounding environment. Recently, determination of the hygroscopicity is of great importance to select the most appropriate solid form of a drug substance for development. The pivotal effect of hygroscopicity evaluation in pharmaceutical development is mainly ascribed to the fact that the up-taken moisture may leads to significant adverse effects on the physical and chemical stability of the end products. For pharmaceutical development, the moisture sorption evaluation is always conducted during the early stages to optimize the formulation parameters, manufacturing process and establish a storage condition for the drug substances or end products.

Our Techniques for Hygroscopicity Testing

Radio frequency based method

Such method is generally based on an analyzer of MCPC Moisture Computer and can be applied for a wide range moisture measurements such as major food products or the processing, some building materials, chemical compounds and bio/pharmaceutical products.

TA represents one of the most efficient, reliable and responsive methods for moisture determination. The primary principle of this methodology is to determine the weight loss of mass post heating the materials being tested at a certain temperature.

This method generally involves a more responsive radiator in heating and cooling requirement cycles than the infrared heaters, which results an accelerated responsiveness and saves the actual test cycle time. More importantly, when combining the thermogravimetric drying and halogen heating with highly accurate weighing technology, it can deliver a faster and more precise procedure for a wide array of moisture analysis.

We also provide clients with oven drying methods, which is commonly used for commercial purposes, such as substance vaporization, capacitance, Karl Fischer Titration, water activity, halogen and infrared drying methods, and the thermogravimetric method of infrared drying technique.

Why Choose BOC Sciences?

BOC Sciences is able to provide a full range of hygroscopicity testing for drugs, chemicals, and even the materials including solids, powders, or tissues. Additionally, with our advanced furnace control system which has a great capacity of ramping the temperature from 25°C to 1100°C, any scale of your products can be tested at our laboratory. By determining whether the drug substance is sensitive to moisture, our scientists help you to make a decision for operational and procedural conditions that ensure the physicochemical stability and the pharmacological activity of your products.


  1. Allada, R. (2016). Hygroscopicity Categorization of Pharmaceutical Solids by Gravimetric Sorption Analysis: A Systematic Approach. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm10(04).
  2. Lawrence, X. Y. (2008). Pharmaceutical quality by design: product and process development, understanding, and control. Pharmaceutical research25(4), 781-791.
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