Reference Compound Synthesis

Reference Compound Synthesis

BOC Sciences provides high-quality reference compound synthesis services. Reliability is the core of our overall service and the principle that we must abide by. We keep a complete log for every step during the process of the reference compound synthesis and ensure high industry standards. Our service agreement also comes with a confidentiality agreement to protect our customers’ privacy and sensitive information.

Materials are classified into two groups by the ISO: reference materials (RMs) and certified reference materials (CRMs). RMs (reference compounds), established for measuring the quality of analysis, are critical for any measurement process characterized by a metrologically valid procedure for one or more specified properties. CRMs are used to check the quality and metrological traceability of products and to validate analytical measurement methods. For pharmaceutical industry, CRMs is the major part of regulatory specification and critical for quality assurance.

Types of reference materials (International Laboratory Accreditation Cooperation describes the following five types of reference material):

  • Pure substances: essentially pure chemicals, characterized for chemical purity.
  • Standard solutions and gas mixtures, often prepared gravimetrically from pure substances.
  • Matrix reference materials, characterized for the composition of specified major, minor or trace chemical constituents. Such materials may be prepared from matrices containing the components of interest or by preparing synthetic mixtures.
  • Physico-chemical reference materials, characterized for properties such as melting point, viscosity, or optical density.
  • Reference objects or artifacts, characterized for functional properties such as taste, odour, octane number, flash point and hardness.

General steps required in production of a certified reference material typically include:

  • Collection or synthesis of materials
  • Sample preparation (including homogenization, stabilization, bottling etc.)
  • Homogeneity testing
  • Stability assessment
  • Value assignment (“characterization” in ISO REMCO terms).

Process of our service:


Why Choose BOC Sciences?

BOC Sciences provides a wide range of chemical reference substances for the applications in research, diagnostics, education and industry. High purity reference material and research grade chemicals are available for analytical research substrates, reference standards, etc. Our high-quality and highly pure reference can also improve the efficiency of your production line by eliminating the need to prepare fresh solutions on a regular basis. Chemical reference substances and research chemicals synthesis services are available upon request with a fast turnaround time.


  1. ILAC, G. (2005). Guidelines for the selection and use of reference materials. International Laboratory Accreditation Cooperation, NSW, Australia.
  2. Linsinger, T. P., Pauwels, J., van der Veen, A. M., Schimmel, H., & Lamberty, A. (2001). Homogeneity and stability of reference materials. Accreditation and quality assurance6(1), 20-25.
  3. Cali, J. P. (1979). The role of reference materials in the analytical laboratory. Fresenius’ Journal of Analytical Chemistry297(1), 1-3.

If you have questions about our services at any time, just give us a call or send us an email at . We will do all we can to meet your needs.

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