BOC Sciences provides comprehensive Nuclear Magnetic Resonance (NMR) testing for liquids, solids, and semi-solids. Our services include structural analysis, quantitative measurement, impurity identification, and R&D support. With advanced instruments and an experienced team, we deliver accurate results quickly, offering flexible solutions tailored to research and industrial needs. Our reliable data has earned recognition from clients in pharmaceuticals, chemicals, and materials, helping streamline R&D and accelerate product development.
NMR testing is a precise analytical method that examines the behavior of atomic nuclei in a magnetic field to reveal molecular structures and chemical environments. It provides information on chemical shifts, coupling constants, and molecular interactions, making it valuable for studying small molecules, proteins, peptides, nucleic acids, and other biochemical samples. Non-destructive and highly reliable, NMR helps R&D teams optimize molecular design and experimental strategies, serving as a core tool in research and product development.
We offer the following NMR testing services to support in-depth molecular structure analysis and research.
Includes 1 NMR and 13NMR, providing information on the chemical environment of specific nuclei within molecules. Ideal for preliminary structure confirmation, functional group identification, and chemical shift analysis. At BOC Sciences, experiments are optimized based on sample characteristics to deliver high-quality, reliable data, supporting R&D and experimental design.
Techniques such as COSY, HSQC, and HMBC are used to resolve the structures of complex molecules and investigate interactions between nuclei. Suitable for natural products, small molecules, and functional compound research. We provide tailored experimental strategies and detailed data interpretation, helping clients obtain comprehensive molecular insights and guide subsequent research.
Including three-dimensional and four-dimensional NMR, used to study complex molecular systems and dynamic processes. This service assists R&D teams in analyzing molecular conformational changes, interactions, and dynamics, supporting advanced structural analysis and functional studies.
By employing polarization transfer techniques, DNP NMR significantly enhances sensitivity, making it ideal for low-abundance nuclei or dilute samples. This technique allows clients to detect previously inaccessible trace information, expanding the depth and scope of molecular research and providing reliable high-precision analytical support.
Contact us and share your requirements, and we will recommend the NMR techniques best suited for your samples.
Small Molecules: Includes organic compounds, drug intermediates, and natural products.
Macromolecules: Includes proteins, nucleic acids, polysaccharides, and functional polymers.
Mixtures and Complexes: Enables quantitative analysis of component ratios using qNMR.
Sample States: Can be solution, solid, or semi-solid/gel form for analysis.
Purity: Small molecules ≥95%; macromolecules free from salts and impurities.
Solubility: Samples must dissolve in common NMR solvents, ensuring clear signals.
Concentration: Small molecules 1–20 mg/mL; macromolecules 0.1–10 mM.
Chemical Stability: Samples must remain stable; sensitive samples need protective conditions.
Samples requiring NMR testing, with or without prior purification, can be submitted using our Sample Submission Form.
Our NMR service platform is equipped with a comprehensive range of high-performance instruments capable of handling both liquid and solid samples, supporting multi-nuclear and multi-dimensional analysis to ensure precise structural characterization, quantitative analysis, and advanced research applications.
Key capabilities include:
| Instrument Type | Sample Type | Supported Nuclei |
| High-Resolution Liquid NMR | Liquid | 1H, 13C, 15N, 19F, 31P |
| High-Field Liquid NMR | Liquid | 1H, 13C, 15N, 19F, 31P |
| Solid-State MAS NMR | Solid | 13C, 15N, 19F, 31P, 23Na, 35Cl, 27Al, 29Si |
| HR-MAS NMR | Semi-solid / Gel | 1H, 13C |
| Automated High-Throughput NMR | Liquid | 1H, 13C |
| Flow / Process NMR | Liquid / Reaction Mixtures | 1H, 13C |
| Multi-Nuclear Probe NMR | Liquid / Solid | 11B, 23Na, 35Cl, 27Al, |
| Multi-Dimensional NMR Platform | Liquid / Solid / Semi-solid | 1H, 13C, 15N, 19F, 31P |
Clients submit their testing requirements, including sample type and objectives, for expert professional evaluation and recommendations.
Samples are submitted according to guidelines, then registered, checked, and prepared to ensure testing accuracy and stability.
A customized NMR testing plan is developed, including nucleus selection, solvents, and experimental parameters, and verified internally.
High-resolution spectra are collected using advanced NMR instruments, monitored by technicians to ensure accurate and reliable data.
Spectral data are analyzed to generate chemical shift tables and structural information, verified through dual professional review.
A comprehensive NMR report, including spectra and analysis summary, is delivered securely with optional technical consultation support.
BOC Sciences' NMR testing services provide precise analysis of molecular structures and chemical environments for a wide range of samples, supporting efficient progress in research and R&D projects.
Our NMR testing services typically offer clients the following result reports:
Equipped with high-field NMR instruments capable of 1D, 2D, and multidimensional experiments, delivering precise structural analysis for complex molecules and diverse sample types.
Our experienced NMR analysis team has completed 300+ structural analysis projects, covering small molecules, natural products, and proteins.
We maintain long-term collaborations with internationally recognized instrument suppliers and research institutions, ensuring continuous access to cutting-edge technologies and methodologies.
We provide high-sensitivity detection and visualized reporting, enabling clients to efficiently obtain reliable structural information and research insights.
Client: A mid-sized biotech company developing novel small-molecule therapeutics
Challenge: The client required precise structural elucidation of newly synthesized compounds, including identification of stereochemistry and functional group connectivity, under tight project timelines.
Solution: BOC Sciences employed high-field NMR spectroscopy, including 1D (1H, 13C) and 2D (COSY, HSQC, HMBC) techniques, to provide comprehensive structural information. Advanced pulse sequences and solvent suppression strategies were implemented to minimize signal interference. Our team delivered full spectral interpretation with annotated spectra and corroborating chemical shift assignments.
Outcome: The client achieved clear structural confirmation in a timely manner, accelerated their lead optimization process, and confidently submitted validated structures for further pharmacological evaluation.
Client: A natural products research institute in North America
Challenge: The client needed to quantify the purity and identify potential impurities in complex plant extracts, where traditional chromatography methods were insufficient due to overlapping peaks.
Solution: BOC Sciences applied quantitative NMR (qNMR) analysis using internal standard calibration, combined with 1D and 2D NMR experiments to resolve overlapping signals. The workflow included automated peak integration, accurate baseline correction, and detailed reporting of relative concentrations of major and minor constituents.
Outcome: The client obtained precise purity data and impurity profiles, enabling better quality control and standardization of extracts for downstream pharmacological testing, with results delivered within a few days.
Client: A contract research organization (CRO) specializing in peptide therapeutics
Challenge: The client required verification of peptide sequences and confirmation of post-synthetic modifications, such as acetylation and phosphorylation, with high confidence to support further development.
Solution: BOC Sciences utilized high-resolution NMR, including 1H, 13C, and 31P spectra, alongside 2D TOCSY and NOESY experiments to map amino acid connectivity and confirm modification sites. Our analysts cross-validated NMR data with molecular modeling to ensure accurate sequence assignments and chemical modification detection.
Outcome: The client received comprehensive NMR reports confirming peptide sequences and modifications, reducing batch-to-batch variability, accelerating product validation, and strengthening support for development pipelines.
Nuclear magnetic resonance (NMR) measures the resonance frequencies of atomic nuclei in an external magnetic field, reflecting subtle changes in their surrounding electronic environment. Different nuclei (such as 1H, 13C, and 31P) produce specific chemical shifts and coupling signals. Through 1D and 2D spectra, NMR can elucidate molecular structures, functional groups, and spatial arrangements, providing both qualitative and quantitative information. BOC Sciences offers high-field NMR instruments and expert spectral analysis, ensuring accurate, reliable data to support research decisions.
NMR testing for cholesterol analyzes the NMR signals of lipoprotein particles in serum or plasma, distinguishing high-density (HDL), low-density (LDL), and very-low-density (VLDL) lipoproteins by particle size and number. Each lipoprotein class produces a characteristic 1H-NMR signal pattern. Quantitative analysis of these signals provides precise insights into cholesterol distribution and related metabolic profiles, delivering molecular-level information for research applications.
Yes, NMR can determine molecular stereochemistry through coupling constants, nuclear Overhauser effect (NOE) experiments, and 2D spectra such as COSY, HSQC, and HMBC. Accurate stereochemical information is critical for newly synthesized small molecules or natural products in structural optimization and functional studies. Our team provides fully annotated spectra and stereochemical interpretations, helping clients obtain reliable conclusions efficiently.
High-field NMR, combined with optimized pulse sequences and signal accumulation techniques, can resolve minor components and trace impurities in complex samples. 2D NMR is especially effective at separating overlapping peaks and identifying low-abundance constituents. BOC Sciences’ expert analysts provide detailed spectral interpretation and qualitative insights, supporting key decisions in chemical research and product development.
NMR can analyze a wide variety of sample types, including small molecules, synthetic organic compounds, natural product mixtures, lipids, and nucleic acids. Both solution-state and solid-state samples can be measured. BOC Sciences offers customized NMR testing protocols, selecting appropriate solvent systems and pulse sequences to ensure precise elucidation of molecular features, meeting the needs of research, chemical analysis, and material development.
The NMR testing service from BOC Sciences provided detailed structural analysis that exceeded our expectations. Their expert interpretation of complex spectra enabled our team to confidently confirm molecular configurations. The technical depth and clarity of their reporting have greatly enhanced our research capabilities.
— Dr. S., Senior Research Scientist, Natural Products Laboratory
BOC Sciences' NMR testing consistently delivers highly reliable and reproducible results. Their meticulous spectral acquisition and advanced 2D NMR techniques gave us precise insights into compound connectivity. This consistency has been invaluable for our analytical workflows.
— Dr. M., Head of Analytical Chemistry, Specialty Chemicals Company
The team at BOC Sciences not only performed NMR analyses but also provided expert guidance in interpreting complex datasets. Their ability to translate spectral data into actionable insights has significantly supported our compound characterization projects.
— Dr. K., Lead Scientist, Biotech Start-up
BOC Sciences' NMR service offers comprehensive molecular characterization with exceptional technical rigor. The detailed spectral reports and expert annotations allowed our team to fully understand molecular structures and interactions, strengthening our internal research and development processes.
— Dr. T., Principal Investigator, Academic Research Institute
