Purity Determination

Purity Determination

The purity determination generally refers to the determination of the purity of a high-purity substance (such as a high-purity metal, a high-purity material, a high-purity gas, etc.) by an appropriate analysis method. In many fields, for example, the manufacturing, substances are most efficient when they’re pure. In addition, the pursuit of a healthy living requires a purer environment, where purity determination is necessary to us. There are two methods for measuring purity:

  • Direct measurement method, for example, the purity of the pure metal is determined by an electrolysis method, and the purity of a pure substance is determined by a gravimetric method. Since the percentage value of purity is large, there are many requirements for the effective number of bits. Therefore, the measurement method must be high-precision and high-accuracy, which limits the purity of the high-purity substance.
  • Indirect measurement method, which measures the content of various impurities in a high-purity substance by a high-accuracy and high-sensitivity method, and then subtracts the percentage of the total amount of impurities measured from the substance to be tested as the purity of the high-purity substance.

Purity DeterminationFig 1 Methods of purity determination

Below is a list of our Purity Determination Techniques (include but not limited to the following):

Spectrophotometry (SP)

Spectrophotometry is a method of qualitatively and quantitatively analyzing a substance by measuring the absorbance of light at a specific wavelength or a certain wavelength range. It has the advantages of high sensitivity, easy operation and fast, and is the most commonly used experimental method in biochemical experiments. Many substances are measured by spectrophotometry. In a spectrophotometer, when the light of different wavelengths is continuously irradiated to a sample solution of a certain concentration, an absorption intensity corresponding to a different wavelength can be obtained.

The method of differential scanning calorimetry to determine the concentration of a substance has the advantages of simple operation, no need for a standard substance, and the purity can be obtained by appropriately processing the DSC curve of the substance as long as the substance purity reaches 98% or more. This method has been widely used in the purity identification of inorganic materials such as metals and alloys.

The mobile phase of gas chromatography is an inert gas, and a gas-solid chromatography method has a large surface area and a certain activity of an adsorbent as a stationary phase. When a multi-component mixed sample enters the column, the adsorption speed of each component in the column is different after a certain period of time due to the different adsorption capacity of the adsorbent for each component. In this way, the components are separated from each other in the column and sequentially detected and recorded in the detector.

Why Choose BOC Sciences?

BOC Sciences has established a powerful platform for purity determination of your products whether it is material or finished product. We offer you full range of analytical services, our scientists are rich in experience, and we have advanced instruments to deal with samples in time at low fees, and take the customer-first concept to take every sample seriously.


  1. Richter, S. , Sargent, M. , Schiel, D. , & Kipphardt, H. . (2013). Known purity-the fundament of element determination by atomic spectrometry. Journal of Analytical Atomic Spectrometry, 28(10), 1540-1543.
  2. Kannappan, V. , & Mannemala, S. S. . (2016). Simultaneous enantioseparation and purity determination of chiral switches of amlodipine and atenolol by liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 120, 221-227.

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