The purity determination generally refers to the determination of the purity of a high-purity substance (such as a high-purity metal, a high-purity material, a high-purity gas, etc.) by an appropriate analysis method. In many fields, for example, the manufacturing, substances are most efficient when they’re pure. In addition, the pursuit of a healthy living requires a purer environment, where purity determination is necessary to us. There are two methods for measuring purity:
Fig 1 Methods of purity determination
Spectrophotometry is a method of qualitatively and quantitatively analyzing a substance by measuring the absorbance of light at a specific wavelength or a certain wavelength range. It has the advantages of high sensitivity, easy operation and fast, and is the most commonly used experimental method in biochemical experiments. Many substances are measured by spectrophotometry. In a spectrophotometer, when the light of different wavelengths is continuously irradiated to a sample solution of a certain concentration, an absorption intensity corresponding to a different wavelength can be obtained.
The method of differential scanning calorimetry to determine the concentration of a substance has the advantages of simple operation, no need for a standard substance, and the purity can be obtained by appropriately processing the DSC curve of the substance as long as the substance purity reaches 98% or more. This method has been widely used in the purity identification of inorganic materials such as metals and alloys.
The mobile phase of gas chromatography is an inert gas, and a gas-solid chromatography method has a large surface area and a certain activity of an adsorbent as a stationary phase. When a multi-component mixed sample enters the column, the adsorption speed of each component in the column is different after a certain period of time due to the different adsorption capacity of the adsorbent for each component. In this way, the components are separated from each other in the column and sequentially detected and recorded in the detector.
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How is purity determined in chemical analysis?
Purity is determined by measuring the proportion of the desired compound relative to impurities using analytical techniques such as high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), and nuclear magnetic resonance (NMR).
What is purity analysis in research?
Purity analysis refers to the evaluation of a compound’s chemical composition to ensure it meets the required specifications for research or manufacturing. This process often involves quantitative and qualitative methods to detect and measure impurities.
How can the purity of a solution be determined?
The purity of a solution can be assessed by applying chromatographic, spectroscopic, or titration-based techniques. The choice of method depends on the chemical nature of the solute, the solvent, and the expected impurities.
What are the common methods for determining impurities?
Impurities can be identified and quantified using methods such as HPLC, GC, MS, NMR, infrared spectroscopy (IR), and elemental analysis. Each method provides different information, from trace-level detection to structural elucidation.
What purity determination capabilities does BOC Sciences provide?
BOC Sciences offers a full suite of purity determination services, including chromatographic, spectroscopic, and elemental analysis. Our expertise enables accurate quantification of target compounds and comprehensive impurity profiling for a wide range of chemical and biochemical samples.
Our services deliver precise quantification of compound purity, ensuring data accuracy for quality control.
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