BOC Sciences, as a professional technical service provider, offers formulation technology support services, focusing on assisting research and industrial teams in pharmaceutical R&D, drug delivery system development, materials science, as well as cosmetics and functional product sectors. We are dedicated to addressing key technical challenges across the entire process from molecular design to application-oriented formulation translation. With extensive project experience in nanodelivery system design, complex colloidal system construction, and multiphase formulation optimization, we provide reliable data support and rational development decision-making guidance during early discovery and process optimization stages, thereby accelerating candidate screening and performance validation.
Innovative formulation refers to advanced drug delivery systems that go beyond conventional dosage forms such as tablets, capsules, and injections. By integrating novel carrier materials, advanced fabrication technologies, and functional design strategies, these systems—such as lipid nanoparticles (LNPs), polymeric nanoparticles, liposomes, and nanoemulsions—are engineered to achieve targeted delivery, environmental responsiveness, prolonged circulation, and enhanced bioavailability, while simultaneously overcoming the inherent limitations of conventional formulations in solubility, stability, and delivery efficiency, thereby significantly improving the overall performance and controllability of active pharmaceutical ingredients in real-world applications.
BOC Sciences develops long-acting dosage forms that regulate drug release behavior to maintain stable therapeutic levels, reduce dosing frequency, and improve patient compliance.
These formulations are suitable for dermatological, cosmetic, personal care, and functional ingredient delivery applications.
The platform utilizes micro- and nanoscale dosage forms to enhance solubility, stability, and bioavailability while protecting active compounds from degradation.
BOC Sciences engineers implantable dosage forms that provide long-term and stable drug release after subcutaneous or localized implantation.
Our scientists design patient-friendly oral and mucosal dosage forms that enable rapid absorption, improved compliance, and enhanced bioavailability.
BOC Sciences provides injectable and inhalation dosage forms that enable rapid onset of action and efficient systemic or local delivery.
We support end-to-end formulation design, optimization, and performance evaluation to transform challenging molecules into stable, scalable, and application-ready systems.
BOC Sciences leverages high-throughput screening (HTS), computational chemistry, and formulation design and screening capabilities to support rational formulation design, carrier selection, excipient compatibility prediction, and rapid optimization of candidate delivery systems.
BOC Sciences maintains a rich inventory of formulation-related raw materials, including functional lipids, PEGylated lipid derivatives, surfactants, polymers, aptamers, and other carrier-building components, enabling flexible material selection for diverse innovative dosage forms.
Supported by a professional scientific team and extensive formulation delivery experience, BOC Sciences provides custom synthesis and modification support for functional excipients, carrier materials, linker structures, and active-loaded components required for complex formulation development.
Our preparation capabilities include microfluidic mixing, high-pressure homogenization, nanoprecipitation, emulsification, and lyophilization services, supporting precise, reproducible, and scalable preparation of lipid, polymeric, suspension, and nanoformulation systems.
As a professional analytical platform, BOC Sciences supports particle size and distribution analysis, morphology characterization and structural evaluation, surface property assessment, encapsulation analysis, and stability-related physicochemical testing.
Our biological evaluation capabilities support in vitro and in vivo assessment of formulation performance, including efficacy-related testing, safety evaluation, cellular uptake, release behavior, biodistribution, and pharmacokinetic (PK) analysis.
Different formulation projects require different delivery routes, carrier materials, payload protection strategies, and release-control designs. BOC Sciences supports customized innovative formulation systems based on administration route and drug payload type, helping clients match active ingredients with suitable dosage forms and delivery technologies.
Provide your compound properties, solubility profile, stability constraints, and target application. Our scientists will design a tailored formulation strategy including carrier selection, process optimization, and performance evaluation.
BOC Sciences first works closely with clients to understand the active compound properties, target dosage form, route of administration, application scenario, solubility limitations, stability risks, release expectations, and performance objectives. Combined with pre-formulation screening, our scientists define the key formulation challenges and establish a customized development strategy.
Our team selects suitable carrier materials, excipients, preparation technologies, and dosage form strategies according to the compound characteristics and delivery requirements.
Candidate formulations are prepared and optimized through appropriate process technologies such as microfluidic mixing, high-pressure homogenization, nanoprecipitation, emulsification, spray drying, or lyophilization. Key parameters including particle size, encapsulation efficiency, dispersion stability, release behavior, and process reproducibility are systematically evaluated and refined.
Optimized formulations are evaluated through physicochemical characterization, stability assessment, and, when required, biological performance assessment. BOC Sciences delivers the developed formulation samples together with a clear technical report covering formulation composition, preparation process, key characterization results, performance interpretation, and recommendations for further development.
Many clients have encountered active compounds with poor aqueous solubility, rapid precipitation, or degradation during formulation screening, making it difficult to achieve consistent performance. BOC Sciences addresses these challenges by first analyzing compound properties, solvent compatibility, and degradation risks, then selecting suitable enabling strategies such as solid dispersion, lipid-based carriers, nanoemulsions, nanosuspensions, or polymeric encapsulation. Candidate formulations are further optimized through excipient screening, particle engineering, and stability-oriented characterization.
Colloidal formulations, lipid nanoparticles, emulsions, and polymeric carriers often show aggregation, droplet coalescence, sedimentation, or batch-to-batch dispersion variation. Our team has supported clients by identifying the root causes through particle size distribution analysis, morphology observation, surface charge evaluation, and formulation composition review. Based on the results, BOC Sciences optimizes surfactant systems, lipid/polymer ratios, mixing conditions, homogenization parameters, and storage environments to improve dispersion stability and formulation uniformity.
Some formulation projects face inconsistent release behavior, burst release, incomplete drug release, or weak correlation between formulation design and delivery performance. BOC Sciences helps clients build more predictable release systems by evaluating matrix structure, carrier degradation, drug-carrier interaction, and diffusion behavior. We then adjust coating layers, polymer composition, lipid phase structure, particle size, or gel network density, followed by release testing and iterative optimization to achieve a more controlled and application-relevant release profile.
Clients frequently obtain promising small-scale formulations that become unstable or inconsistent when preparation conditions change. BOC Sciences supports process translation by reviewing the original formulation method, identifying critical preparation variables, and establishing reproducible process parameters. Depending on the formulation type, we apply microfluidic mixing, high-pressure homogenization, emulsification, lyophilization, or controlled drying strategies, then verify key attributes such as particle size, encapsulation efficiency, appearance, redispersibility, and formulation stability across repeated preparation batches.
Collaborate with BOC Sciences to transform challenging active compounds into advanced formulation systems with improved solubility, stability, delivery efficiency, release control, and application-ready performance through rational design, material selection, process optimization, and integrated characterization.
BOC Sciences has a professional formulation team with expertise in pharmaceutical sciences, drug delivery, colloid chemistry, polymer materials, lipid systems, and analytical characterization. Our scientists understand how compound properties, carrier materials, preparation processes, and delivery routes interact, enabling clients to receive technically grounded formulation strategies rather than generic development suggestions.
Our innovation capability is built on formulation design, material selection, carrier engineering, and process optimization. BOC Sciences supports advanced dosage forms such as LNPs, liposomes, polymeric nanoparticles, nanoemulsions, solid dispersions, microneedle formulations, in situ gels, microspheres, and implantable systems, helping clients explore new solutions for challenging drug payloads and delivery barriers.
BOC Sciences has supported diverse formulation projects involving poorly soluble small molecules, nucleic acid payloads, proteins, peptides, hydrophobic compounds, combination payloads, and functional materials. This practical experience allows our team to identify common formulation risks early, select appropriate technologies, and design development workflows that match the client's target dosage form and application needs.
Our formulation evaluation system integrates physicochemical characterization, stability assessment, release testing, morphology observation, encapsulation analysis, and biological performance evaluation. By combining formulation preparation with data-driven testing, BOC Sciences helps clients compare candidates, understand failure mechanisms, optimize key parameters, and make reliable decisions before advancing selected formulations.
Client Needs: A drug delivery research team needed to optimize a lipid nanoparticle formulation for a negatively charged nucleic acid payload. The client expected improved encapsulation efficiency, narrower particle size distribution, and reduced aggregation during buffer exchange and storage.
Challenges: The initial LNP candidates showed broad size distribution, inconsistent encapsulation, and aggregation under different ionic strength conditions. Small changes in lipid ratio, mixing speed, and aqueous phase composition strongly affected particle formation.
Solution: BOC Sciences established a formulation exploration workflow using ionizable lipid ratio screening, helper lipid adjustment, PEG-lipid optimization, and microfluidic mixing parameter evaluation. More than 32 LNP variants were prepared, followed by particle size, PDI, zeta potential, encapsulation efficiency, morphology, and storage stability comparison to identify composition-process combinations with balanced delivery performance.
Outcome: The optimized LNP formulation showed improved particle uniformity, higher payload encapsulation, and better dispersion stability, providing the client with a prioritized formulation candidate for further functional evaluation.
Client Needs: A pharmaceutical development group required a formulation strategy for a poorly water-soluble small molecule containing multiple aromatic rings and a weakly basic functional group. The main objective was to improve apparent solubility and dissolution behavior without causing rapid recrystallization.
Challenges: The compound crystallized quickly from supersaturated solutions and showed poor dispersion in aqueous media. Conventional co-solvent and surfactant approaches provided only temporary solubilization and failed to maintain stable dissolution performance.
Solution: Our team compared nanocrystal, amorphous solid dispersion, and self-emulsifying formulation routes through a stepwise screening workflow. Polymer miscibility, drug-polymer interaction, spray-drying parameters, particle morphology, crystallinity, dissolution profiles, and short-term stability were evaluated across 24 prototypes to select a formulation pathway that minimized recrystallization while improving dissolution consistency.
Outcome: A polymer-based amorphous solid dispersion was selected as the most promising formulation, showing improved dissolution behavior and reduced crystallization tendency during comparative stability testing.
Client Needs: A functional materials team needed to improve the stability of a polymer emulsion used for an active coating application. The formulation required uniform droplet distribution, suitable viscosity, and resistance to phase separation during thermal cycling.
Challenges: Early emulsion batches showed droplet coalescence, creaming, and viscosity drift after repeated heating and cooling. The instability was linked to interfacial tension mismatch, insufficient emulsifier coverage, and sensitivity to processing shear conditions.
Solution: BOC Sciences designed an emulsion screening workflow covering emulsifier type, co-stabilizer ratio, oil-water phase balance, homogenization pressure, mixing sequence, and temperature profile. Fifteen batches were prepared and evaluated by droplet size distribution, optical microscopy, rheology, centrifugation stress testing, and thermal cycling to identify the formulation-process window with improved colloidal stability.
Outcome: The final emulsion formulation displayed more uniform droplet distribution, reduced phase separation tendency, and improved viscosity stability, supporting the client's coating performance evaluation and process refinement.
Innovative formulation technologies are typically suitable for drug projects facing low solubility, limited permeability, uncontrolled release, poor physical stability, irritation risk, or route-of-administration constraints. For small-molecule candidates, peptides, nucleic acid drugs, natural product derivatives, and complex lipophilic compounds, BOC Sciences can evaluate formulation routes such as solid dispersions, lipid-based systems, nanoparticles, microspheres, gels, transdermal delivery, and topical delivery. This helps research teams identify practical formulation strategies earlier and reduce uncertainty during candidate optimization.
Technology selection for poorly soluble drugs should not depend only on solubility values. It also requires consideration of logP, pKa, melting point, crystallization tendency, dose range, dissolution behavior, and intended administration route. For high-melting or crystallization-prone molecules, amorphous solid dispersion may improve dissolution performance. For highly lipophilic molecules, lipid-based systems may be more suitable. For projects requiring particle-size control or delivery-system research, nanoemulsions, polymeric nanoparticles, or lipid nanoparticles can also be screened. BOC Sciences commonly uses preformulation assessment and small-scale formulation matrices to narrow down feasible technical routes.
BOC Sciences first defines the desired release profile, such as rapid onset, extended release, pulsatile release, gastric-retentive release, or localized retention. We then design the formulation based on drug solubility, diffusion behavior, carrier compatibility, and dosage-form structure. Common strategies include polymer matrix modulation, coating-layer adjustment, lipid carrier composition optimization, microsphere particle-size control, gel network design, and multi-unit release systems. Dissolution profiles, particle-size distribution, morphology observation, and stability-related tests are used to compare release consistency and application suitability.
Nanoformulations can help improve the dispersion of hydrophobic drugs, protect degradation-sensitive ingredients, modulate release behavior, enhance compatibility with cellular uptake studies, and support oral, injectable, topical, or mucosal delivery research. Common systems include lipid nanoparticles, polymeric nanoparticles, nanoemulsions, micelles, and organic/inorganic hybrid carriers. In project development, BOC Sciences focuses on particle size, PDI, zeta potential, loading behavior, precipitation risk, storage behavior, and medium compatibility. This avoids formulations that are merely “processable” but lack stability or reproducibility in downstream research.
Drug formulation screening should rely on multidimensional data rather than a single metric. For oral or injectable candidates, key evaluations often include solubility, dissolution rate, precipitation risk, pH dependence, drug loading, particle-size distribution, appearance changes, compatibility, thermal behavior, crystallization tendency, and storage-related changes. For topical, transdermal, or long-acting systems, viscosity, spreadability, release profile, and performance in skin or tissue-related models may also be important. BOC Sciences can integrate formulation experiments, analytical testing, and comparative data interpretation into clear screening outputs to support the next optimization step.
The formulation team helped us significantly improve the stability and reproducibility of our lipid nanoparticle system, especially under challenging storage conditions.
— Senior Scientist, Drug Delivery Research
We were struggling with a poorly soluble compound, and their solid dispersion approach clearly improved dissolution performance and formulation consistency.
— Project Leader, Pharmaceutical Development
Their optimization of emulsifier systems and processing conditions helped eliminate phase separation issues in our coating formulation.
— Materials Scientist, Industrial Formulation Team
If you have any questions or encounter issues on this page, please don't hesitate to reach out. Our support team is ready to assist you.
