Custom Antibiotic Synthesis

Custom Antibiotic Synthesis

Antibiotics are a class of secondary metabolites with anti-pathogen or other activities produced by microorganisms (including bacteria, fungi, actinomycetes) or higher animals and plants in the course of life, which can interfere with the development of other living cells. Based on the elaborate chemical synthesis platform and experienced chemical experts, BOC Sciences provides comprehensive customized antibiotic.

Classification of Antibiotics

Antibiotics are generally classified based on their chemical structure, application, or synthesis methods.

Chemical Structure: Quinolone antibiotics; β-lactam antibiotics; macrolides; aminoglycoside antibiotics, etc.

Application: Antibacterial antibiotics, antifungal antibiotics, antitumor antibiotics, antiviral antibiotics, animal antibiotics, agricultural antibiotics and other microbial drugs, etc.

Synthesis method: Penicillin biosynthesized by microbial fermentation; sulfonamide and quinolone antibiotics obtained by chemical synthesis; semi-synthetic antibiotics are derivatives of antibiotics obtained by biosynthesis by chemical, biological or biochemical methods.

Custom Antibiotic Synthesis

Mode of Action of Antibiotic

Inhibits cell wall synthesis: β-lactam antibiotics can bind to the penicillin-binding proteins (PBPs) to inhibit the synthesis of the cell wall.

Interact with the cell membrane: Antibiotics interact with the cell membrane of the cell to affect the permeability of the membrane, causing important substances such as salt ions, proteins, nucleic acids and amino acids in the bacteria to leak out, which has a fatal effect on the cell.

Interferes with protein synthesis: Tetracyclines, macrolides, aminoglycosides, and chloramphenicol antibiotics with sterilization function by interacting with the bacterial ribosome or its reaction substrate (such as tRNA, mRNA) to inhibit the synthesis of bacterial proteins.

Inhibits nucleic acid replication and transcription: They can inhibit the function of bacterial nucleic acids, thereby preventing cell division and/or synthesis of required enzymes.

Our Common separation and purification methods

Solvent extraction: it is also called liquid-liquid extraction (LLE) and partitioning, is a method to separate compounds based on their relative solubilities in two different immiscible liquids. As a traditional separation technique, solvent extraction is still widely used in the industrial production of antibiotics, such as spiramycin, lincomycin, penicillin, etc.

Precipitation: It is widely used in the extraction of macromolecules such as proteins. It mainly plays the role of concentration, and the effect of purification is poor. It is usually used as a method of preliminary separation.

Crystallization: It is a technique used for the purification of substances. A separation technique to separate solids from a solution.

Adsorption: It is to use the molecular attraction between the adsorbent and antibiotic and the antibiotic adsorption on the adsorbent. The commonly used adsorbents are activated carbon, alumina, macroporous adsorption resin.

Chromatography: It is an analytical technique commonly used for separating a mixture of chemical substances into its individual components, so that the individual components can be thoroughly analyzed.

Our Services

  • Fermentation of antibiotics
  • Chemical synthesis of antibiotics
  • Semi-synthetic antibiotics
  • Isolation and purification of antibiotics

Our Capability

  • Over 100,000 liters of large-scale fermentation capability
  • A broad range of downstream processing covers microfiltration, centrifugation, liquid/liquid extraction, ultrafiltration, evaporation and packaging.
  • With a comprehensive portfolio of analytical competences
  • Quality assurance in every process, delivering high-quality products consistently.
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