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Raman Testing

Raman Testing

At BOC Sciences, we provide comprehensive Raman Testing services for both research and industrial applications, offering precise chemical composition analysis, molecular structure characterization, trace detection, and volumetric analysis for solids, liquids, films, and composite materials. Leveraging advanced instrumentation and an experienced analytical team, we deliver high-quality, reliable data and in-depth analytical reports to support product development, material optimization, and quality control. Trusted by research institutions and industrial clients worldwide, our services provide actionable insights and efficient solutions to meet diverse R&D and production needs.

What is Raman Testing?

Raman testing is a non-destructive analytical technique first discovered by Indian physicist C.V. Raman in 1928. It relies on the interaction between laser light and molecular vibrations to produce scattered light, most of which is elastically scattered, hile a small fraction undergoes energy shifts, orming inelastic (Raman) scattering. Each molecule and chemical bond exhibits characteristic vibrational modes, and the resulting Raman spectrum acts as a unique "fingerprint" that reveals the chemical composition and molecular structure of the sample. By analyzing these spectral peaks and intensities, R&D and industrial teams can identify molecular types, chemical bonds, and intermolecular interactions. Raman testing is suitable for solids, liquids, films, and composite materials, providing reliable structural and compositional insights to support product development, materials optimization, and quality control.

BOC Sciences Comprehensive Raman Testing

We offer the following Raman testing services to support precise analysis of material and sample structures.

Standard Raman Testing

Standard Raman Testing uses monochromatic laser excitation to detect inelastic scattering from samples. Both dispersive (grating) and Fourier-transform (FTRaman) instruments are available, with FTRaman offering improved fluorescence suppression. Ideal for material structure analysis, polymer characterization, and rapid solid or liquid sample testing.

Resonance Raman Testing

Resonance Raman Testing significantly enhances Raman signals when the laser wavelength matches electronic transitions. It is suitable for high-sensitivity detection of biological macromolecules such as pigments and hemoglobin, as well as metal complexes, providing precise compositional and structural insights.

Surface-Enhanced Raman Testing (SERS)

Surface-Enhanced Raman Testing employs metal nanostructures, typically gold or silver, to create strong electromagnetic fields, increasing Raman signals by 106–108 times. It is widely used for trace chemical detection, drug residue analysis, food safety, and rapid on-site sample identification.

Non-linear Raman Testing

Non-linear Raman Testing includes CARS, SRS, and time-resolved Raman, utilizing non-linear light interactions to improve signal-to-noise ratios and imaging speed. Applications include tissue imaging, chemical kinetics studies, and real-time monitoring of live cells in research and industrial contexts.

Spatially Offset Raman Testing (SORS)

Spatially Offset Raman Testing enables non-destructive analysis of deep or encapsulated samples by offsetting the laser excitation from the measurement point. This method is ideal for examining tablet interiors, packaged materials, and other samples where surface measurements are insufficient.

Transmission Raman Testing (TRS)

Transmission Raman Testing collects Raman signals transmitted through samples, making it suitable for thick or bulk materials. It is extensively applied in pharmaceutical quality control, industrial raw material inspection, and situations requiring rapid volumetric analysis of solid samples.

Need Expert Raman Analysis?

Contact BOC Sciences today with your material information, and we will guide you to the Raman testing services that fit your research or production needs.

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Sample Types Supported by Our Raman Testing

MTT Assay

Supported Sample Types

Solutions: Aqueous, organic solvents, ionic solutions, suitable for measurement.

Solids: Powders, crystals, thin films, pellets, measured directly or prepared.

Colloids and Suspensions: Nanoparticles, emulsions, and colloids, analyzed with SERS if needed.

Gases: Specific gases or vapors measurable using proper gas cells.

CCK-8 Assay

Sample Requirements

Optical Properties: Samples should allow sufficient Raman scattering without strong fluorescence.

Solution Quality: Must be homogeneous, bubble-free, and free of large particulates.

Volume and Containers: Solids mg scale, liquids in cells, gases adjust pressure.

Raman Testing – Sample Submission Form

Submit your sample with key details for precise Raman analysis today.

Submit Your Sample

Complete and Advanced Raman Testing Platform

Our Raman service platform at BOC Sciences is equipped with a full range of high-performance instruments capable of handling solids, liquids, thin films, and complex composite materials. The platform supports micro-scale mapping, surface-enhanced detection, non-linear imaging, and subsurface/volume analysis, ensuring precise chemical composition, molecular structure characterization, and advanced research or industrial applications.

Instrument TypeDescriptionApplicable Samples
Micro-RamanCombines a microscope to achieve high spatial resolution (≈1 µm), enabling point measurements or mapping of single cells or microstructuresSingle cells, micro-particles, microstructures, localized material regions
Portable / Handheld RamanCompact, portable devices for rapid on-site detection, often equipped with fiber-optic probesPharmaceuticals, chemicals, food, environmental samples for fast field testing
Fiber-optic RamanUses fiber-optics to deliver laser light into hard-to-reach samples, suitable for on-site or industrial online monitoringIndustrial pipes, reaction vessels, inaccessible samples, online monitoring materials
Near-field / TERS RamanUtilizes a metallic probe to generate a localized strong field, achieving nanoscale resolution (≈10 nm)Nanomaterials, thin films, surface-localized structures, specialized research samples
FT-RamanEmploys an interferometer to acquire full spectra with strong fluorescence suppression, ideal for organic polymers, dyes, and high-fluorescence samplesOrganic polymers, dyes, fluorescent samples, polymer materials
Dispersive RamanTraditional grating-based dispersion, with selectable laser wavelengths (532 nm, 785 nm, 1064 nm)Solids, liquids, films, powders, and standard laboratory samples

Raman Testing Workflow at BOC Sciences

Requirement Understanding

1Technical Consultation and Requirement Assessment

Clients submit sample information and objectives. Our scientists evaluate feasibility and provide customized Raman analysis plans.

Experimental Design

2Sample Preparation Guidance

We advise optimal sample handling, including particle adjustment, solvent selection, and contamination-free packaging for reliable analysis.

Model System Construction

3Sample Receipt and Integrity Verification

Samples are logged, inspected for uniformity, and evaluated for special treatments to ensure reliable Raman data collection.

Pharmacological Testing Execution

4High-Precision Raman Spectral Acquisition

Using high-resolution spectrometers with multi-wavelength lasers, we optimize parameters to obtain high signal-to-noise spectra accurately.

Data Collection and Analysis

5Professional Data Processing and Multi-Dimensional Analysis

Spectra undergo baseline correction, peak fitting, and database comparison for precise composition and structural interpretation.

Report Delivery

6Structured Report Generation and Technical Interpretation

Final reports include spectra, composition, structure analysis, and scientist-reviewed interpretation to support client understanding.

Contact Us to Quickly Start Your Raman Testing Services

BOC Sciences' Raman testing services provide highly sensitive, non-destructive analysis of molecular structures and sample states, supporting efficient progress in research projects and enabling reliable data for R&D and scientific decision-making.

Request a Quote

Overview of Raman Testing Report Materials

Clients typically receive comprehensive reports from our Raman testing services:

Sample Information

  • Sample name, ID, batch number, source.
  • Sample state: solid, liquid, or powder.
  • Sample preparation: solvent, concentration, treatment method.

Testing Conditions and Raw Data

  • Testing conditions: laser wavelength, power, and scan count.
  • Raw spectral data: Raman shift, intensity, spectral files.
  • Instrument calibration, operation records ensure reliability.

Data Analysis and Test Report

  • Spectrum analysis: peak positions, assignments, structural features.
  • Test conclusions: chemical composition, structural information provided.
  • Formal report: number, date, method, analyst signature.

Advantages of Our Raman Testing Services

Advanced Instrumentation

Leveraging BOC Sciences' state-of-the-art Raman spectrometers, we provide precise analysis for both routine and complex samples, backed by extensive experience and accumulated data.

Experienced Professional Team

Our scientific team has years of expertise in Raman spectroscopy research and applications, handling a wide variety of sample analyses across numerous research and industrial projects.

Strong Collaborative Network

Close collaborations with renowned domestic and international research institutions and industry partners enable us to access cutting-edge technical support, enhancing data interpretation and result depth.

Efficient Problem-Solving Capability

By integrating advanced instrumentation, expert knowledge, and collaborative resources, we offer flexible, customized analytical solutions to address challenges presented by complex samples.

Applications Supported by Our Raman Testing

Characterization Support

Formulation Analysis

  • Excipient Compatibility and Mixture Analysis
  • Dosage Development
  • Non-destructive In Situ Monitoring of Formulations
  • Pre-Formulation Screening

Drug Discovery Support

Raman Testing Case Studies and Success Stories

Challenge: The client needed rapid and non-destructive identification of incoming raw materials to ensure authenticity and prevent adulteration, without interrupting production timelines.

Solution: BOC Sciences implemented state-of-the-art Raman spectroscopy systems with fiber-optic probes for at-line testing. Our team developed custom spectral libraries for each raw material and optimized laser wavelength and acquisition parameters to minimize fluorescence interference. The workflow included automated spectral matching and real-time reporting.

Outcome: The client achieved rapid raw material verification, streamlined sample preparation, and successfully integrated Raman testing into their quality assurance workflow, enabling efficient, reliable, and data-driven quality control processes.

Client: Global pharmaceutical R&D center

Challenge: The client required precise differentiation of polymorphic forms of a drug compound during formulation development, as polymorphs could affect bioavailability and stability.

Solution: BOC Sciences applied high-resolution Raman microscopy and mapping techniques, enabling spatially resolved analysis of solid-state forms. We provided comprehensive spectral databases and software-assisted peak deconvolution to accurately distinguish polymorphs, even in complex mixtures.

Outcome: The client gained rapid, non-destructive polymorph identification, accelerated formulation optimization by 30%, and minimized batch-to-batch variability risks.

Client: Premium cosmetic brand in Europe

Challenge: The client needed to verify ingredient composition and detect contamination in cream and lotion formulations, ensuring compliance with internal quality standards.

Solution: BOC Sciences deployed portable Raman analyzers and benchtop systems with enhanced sensitivity for complex matrices. Our team tailored spectral acquisition parameters for emulsions and provided automated spectral comparison against validated reference profiles. Data analysis included quantitative assessment of active ingredients and identification of trace contaminants.

Outcome: The client achieved fast, on-site quality verification, improved detection of formulation inconsistencies, and enhanced consumer safety assurance, all while reducing laboratory testing costs and turnaround time.

Frequently Asked Questions

Frequently Asked Questions

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Client Reviews: Raman Testing Services

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