BOC Sciences' custom carbohydrate synthesis service can take orders in sizes ranging from milligrams, grams, kilograms to above. Comprehensive compound testing reports can be complemented with each order. Our quality service also comes with competitive price and efficiency.
Coming from an important group of natural products, carbohydrates are involved in complex biological processes such as in vital cellular recognition processes, carbohydrate-protein interactions, and targeting of hormones, antibodies, pathogenic toxins and microorganisms. Moreover, they can form a huge number of branching complex structures because of their structural diversity in terms of functional groups, ring size, and linkages. For chemists, carbohydrates are interesting as chiral-pool materials and as building blocks for the synthesis of natural products and drugs. The complexity and diversity of carbohydrates found in nature, however, make the synthesis a challenging task.
Custom Carbohydrate Synthesis Services
Sonication in carbohydrate synthesis
Sonication, as a means of promoting organic reactions in carbohydrate chemistry, was explored under the conditions used for traditional organic synthesis. A series of representative reactions, such as hydroxy group manipulation (acylation, protection/deprotection, acyl group migration), thioglycoside synthesis, azidoglycoside synthesis, 1,3-dipolar cycloaddition and reductive cleavage of benzylidene, commonly used in the synthesis of carbohydrate derivatives. Sonication can significantly shorten the reaction time, enhance the reactivity of reactant and lead to superior yield and excellent stereoselectivity.
Figure 1. The synthetic route of sonication in carbohydrate synthesis
Valuable organocatalysts in carbohydrate synthesis
Enolizable achiral aldehydes and ketones, for instance, can be converted with proline (derivatives) into the corresponding enamines, which can then react with less enolizable carbonyl compounds, even in one-pot protocols and often with high selectivities.
Regioselective acylation carbohydrate synthesis
Carbohydrate esters are biodegradable, and the degraded adducts are naturally occurring carbohydrates and fatty acids which are environmentally friendly and non-toxic to human. A simple one-step regioselective acylation of mono-carbohydrates has been developed that results in the synthesis of enormous carbohydrate esters.
CRO/CDMO Capabilities & Manufacturing
BOC Sciences operates as both a CRO and CDMO for carbohydrate synthesis.
- Flexible scale: from milligram-scale for discovery projects to multi-kilogram manufacturing campaigns.
- Process development: solvent and catalyst screening, impurity control, and robustness testing to ensure consistent quality and reliable performance.
- Manufacturing support: technology transfer, validated analytical methods, and robust documentation.
Our platform bridges research and industrial production, ensuring clients can transition from idea to drug candidate smoothly.
Carbohydrate Synthons & Building Blocks
A robust synthesis program begins with the right carbohydrate synthons:
- Glycosyl donors such as thioglycosides, trichloroacetimidates, and halides, tailored to control reactivity and selectivity.
- Glycosyl acceptors with selective hydroxyl groups exposed, ready for regioselective coupling.
- Protected monosaccharides (acetyl, benzyl, mixed schemes) for convergent synthesis of larger glycans.
- Functionalized linkers enabling glycoconjugate construction with peptides, lipids, or fluorophores.
By offering customizable synthons, we shorten route scouting and provide reproducible starting points for complex assemblies.
Capabilities by Molecule Type
Our expertise spans the full spectrum of carbohydrate classes:
- Monosaccharides & rare sugars: access to uncommon stereo-chemistries and isotopically labeled forms.
- Oligosaccharides: iterative or convergent strategies using orthogonal protecting groups.
- Polysaccharide fragments: tailored depolymerization and controlled re-assembly methods.
- Glycoconjugates: glycopeptides, glycolipids, glycopolymers, and fluorescently labeled derivatives.
- Material-oriented glycans: surface immobilization strategies for assays, biosensors, and biomaterials.
This broad portfolio supports applications in glycobiology, vaccine development, diagnostics, and materials science.
Deliverables, Characterization & Quality
Every synthesis project is accompanied by a transparent data package:
- Analytical certificate: high-purity compounds (per client specification), supported by HPLC/GC, HRMS, and 1D/2D NMR.
- Synthetic route report: protecting-group schemes, glycosylation strategies, and key intermediates.
- Structural confirmation: stereochemistry verified through advanced NMR and, if needed, crystallography.
- Optional services: impurity profiling, stability studies, and residual metal analysis.
These deliverables ensure confidence in reproducibility, scalability, and compliance for both research and development use.
Workflow, Timelines & Confidentiality
Our carbohydrate synthesis projects follow a structured process:
- Scoping defines the targets, specifications, and scale requirements.
- Route design proposes protecting-group strategies, glycosylation methods, and risk assessments.
- Synthesis and optimization execute reactions with parallel scouting to improve efficiency.
- Scale-up and manufacturing moves the process from laboratory demonstration to pilot and commercial scale.
- Delivery and reporting provide compounds with full analytical documentation.
Throughout the process, we adhere to strict confidentiality, data integrity, and client-specific compliance requirements.
Why Choose BOC Sciences?
At BOC Sciences, our experts will work with you to optimize the carbohydrate synthetic route and approaches. Customer services are also available at any time.
Advance glycobiology with BOC Sciences carbohydrate synthesis
We provide carbohydrate synthesis from monosaccharides to complex oligosaccharides, ensuring high purity and structural accuracy. Our methods support applications in glycobiology and material sciences.
Submit your inquiry to request a custom solution.
References
- Creech, R. G. (1965). Genetic control of carbohydrate synthesis in maize endosperm. Genetics, 52(6), 1175.
- McArthur, J. B., & Chen, X. (2016). Glycosyltransferase engineering for carbohydrate synthesis. Biochemical Society Transactions, 44(1), 129-142.
If you have questions about our services at any time, just give us a call or send us an email at . We will do all we can to meet your needs.
Our Highlights
- Advanced computer aided technology
- Custom synthesis for small molecules
- One-stop, systematic services
- Experienced technical team
- Technical support, quality assurance
