Carbohydrate Synthesis

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Carbohydrate Synthesis

Carbohydrates, an important class of natural products, play a wide range of key roles in complex biological processes involving specific events in vital cellular recognition processes, carbohydrate-protein interactions, and targeting of hormones, antibodies, pathogenic toxins and microorganisms. Moreover, they can form a huge number of branching complex structures because of their structural diversity in terms of functional groups, ring size and linkages. For chemists, they are interesting as chiral-pool materials and as building blocks for the synthesis of natural products and drugs. The complexity and diversity of carbohydrates found in nature, however, makes the synthesis of carbohydrates a challenging task.

Below is a list of our Carbohydrate Synthesis Services (include but not limited to the following):

Sonication in carbohydrate synthesis

Sonication, as a means of promoting organic reactions in carbohydrate chemistry, was explored under the conditions used for traditional organic synthesis. A series of representative reactions, such as hydroxy group manipulation (acylation, protection/deprotection, acyl group migration), thioglycoside synthesis, azidoglycoside synthesis, 1,3-dipolar cycloaddition and reductive cleavage of benzylidene, commonly used in the synthesis of carbohydrate derivatives. Sonication can significantly shorten the reaction time, enhance the reactivity of reactant and lead to superior yield and excellent stereoselectivity.

Carbohydrate Synthesis Figure 1. The synthetic route of sonication in carbohydrate synthesis

Enolizable achiral aldehydes and ketones, for instance, can be converted with proline (derivatives) into the corresponding enamines, which can then react with less enolizable carbonyl compounds, even in one-pot protocols and often with high selectivities.

Carbohydrate esters are biodegradable, and the degraded adducts are naturally occurring carbohydrates and fatty acids which are environmentally friendly and non-toxic to human. A simple one-step regioselective acylation of mono-carbohydrates has been developed that results in the synthesis of enormous carbohydrate esters.

Why Choose BOC Sciences?

BOC Sciences provides high-quality, low-cost, high-tech products to customers around the world. We has employed a dedicated staff of professional chemists to help you develop the most efficient process for synthesis of complex drug substances. With diverse state-of-the-art technologies and approaches, clients’ synthetic route can be developed and optimized in the most cost effective way. Each step of product synthesis is subject to BOC Sciences’ stringent quality control. Typical delivery specifications include:

  • In quantities of several milligrams up to 100 grams.
  • Additional analyses, such as stability determination, impurity analysis, and residual solvents etc.
  • With diverse state-of-the-art technologies and approaches.
  • Quality assurance: HPLC chromatogram and Mass spec analysis.
  • Overnight shipping with suitable packs.

At BOC Sciences, our customers will be resourced with various kinds of synthetic and analytical instrumentations. Our experts will work with you to optimize the carbohydrate synthetic route and approaches. Additionally, according to your needs and the properties of chemical substances, a wide range of custom services are available in our laboratory. If you would like BOC Sciences to help you synthesis your products, please contact us!

References

  1. Creech, R. G. (1965). Genetic control of carbohydrate synthesis in maize endosperm. Genetics, 52(6), 1175.
  2. McArthur, J. B., & Chen, X. (2016). Glycosyltransferase engineering for carbohydrate synthesis. Biochemical Society Transactions, 44(1), 129-142.
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