Carbohydrate Synthesis

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Carbohydrate Synthesis

BOC Sciences’ custom carbohydrate synthesis service can take orders in sizes ranging from milligrams, grams, kilograms to above. Comprehensive compound testing reports can be complemented with each order. Our quality service also comes with competitive price and efficiency.

Coming from an important group of natural products, carbohydrates are involved in complex biological processes such as in vital cellular recognition processes, carbohydrate-protein interactions, and targeting of hormones, antibodies, pathogenic toxins and microorganisms. Moreover, they can form a huge number of branching complex structures because of their structural diversity in terms of functional groups, ring size, and linkages. For chemists, carbohydrates are interesting as chiral-pool materials and as building blocks for the synthesis of natural products and drugs. The complexity and diversity of carbohydrates found in nature, however, make the synthesis a challenging task.

Below is a list of our Carbohydrate Synthesis Services (include but not limited to the following):

Sonication, as a means of promoting organic reactions in carbohydrate chemistry, was explored under the conditions used for traditional organic synthesis. A series of representative reactions, such as hydroxy group manipulation (acylation, protection/deprotection, acyl group migration), thioglycoside synthesis, azidoglycoside synthesis, 1,3-dipolar cycloaddition and reductive cleavage of benzylidene, commonly used in the synthesis of carbohydrate derivatives. Sonication can significantly shorten the reaction time, enhance the reactivity of reactant and lead to superior yield and excellent stereoselectivity.

The synthetic route of sonication in carbohydrate synthesis Figure 1. The synthetic route of sonication in carbohydrate synthesis

Enolizable achiral aldehydes and ketones, for instance, can be converted with proline (derivatives) into the corresponding enamines, which can then react with less enolizable carbonyl compounds, even in one-pot protocols and often with high selectivities.

Carbohydrate esters are biodegradable, and the degraded adducts are naturally occurring carbohydrates and fatty acids which are environmentally friendly and non-toxic to human. A simple one-step regioselective acylation of mono-carbohydrates has been developed that results in the synthesis of enormous carbohydrate esters.

Why Choose BOC Sciences?

Advantage-of-Custom-Synthesis-Carbohydrates

At BOC Sciences, our experts will work with you to optimize the carbohydrate synthetic route and approaches. Customer services are also available at any time.

References

  1. Creech, R. G. (1965). Genetic control of carbohydrate synthesis in maize endosperm. Genetics, 52(6), 1175.
  2. McArthur, J. B., & Chen, X. (2016). Glycosyltransferase engineering for carbohydrate synthesis. Biochemical Society Transactions, 44(1), 129-142.
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