HTS Libraries

High throughput screening (HTS) technology is based on experimental methods at the molecular and cellular levels...

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HTS Libraries

High throughput screening (HTS) technology is based on experimental methods at the molecular and cellular levels, using microplate format as an experimental tool carrier, performing an experimental process with an automated operating system, collecting experimental data with sensitive and rapid detection instruments, and processing computer data with computer analysis. It detects tens of millions of samples at the same time, and supports the running technical system with the corresponding database. HTS is micro, fast, sensitive and accurate. In short, you can get a lot of information in one experiment and find valuable information from it.

High-throughput-screening-libraries

Below is a list of our HTS Libraries Services (include but not limited to the following):

Discovery of new targets for drug action

The client provides a screening sample and selects a screening chip, which is detected by SPR (Surface Plasmon Resonance), combined with component elution and collection, and finally subjected to mass spectrometry to identify the target.

The client provides the target molecule, we will predict the target structure, calculate the virtual screening of the compound library, select the compound, then identify it, and finally provide the test data.

Receptor screening model: Screening methods targeting receptors include detecting functional responses, second messenger generation, and labeling ligand-receptor interactions.

Enzyme screening model: Observe the effect of the drug on enzyme activity. According to the characteristics of the enzyme, the reaction substrate of the enzyme and the product can be used as detection indexes, and the reaction rate is determined thereby.

Ion channel screening model: (1) High-throughput screening of shellfish toxins, the target of which is the scorpion toxin binding site on the Na+ channel, and the test sample was investigated by a competitive binding assay with radioligand. (2) High-throughput screening of small molecules that interfere with the interaction of the N-type calcium channel β3 subunit with the α1β subunit by yeast two-hybrid method, looking for a novel calcium channel antagonist.

Why Choose BOC Sciences?

BOC Sciences has a collection of more than 1.6 million compounds involving 5000 skeletons and 300 potential targets for high-throughput screening and high-content screening. In the design and screening of compound libraries, we have identified a range of methods to ensure the diversity and high specificity of compound libraries. These libraries have been extensively validated in our in-house bioassays and validated in external partner laboratories, including pharmaceutical, biotechnology, academic and screening centers.

References:

  1. List, M. , Elnegaard, M. P. , Schmidt, S. , Christiansen, H. , Tan, Q. , & Mollenhauer, J. , et al. (2016). Efficient management of high-throughput screening libraries with savanah. Journal of Biomolecular Screening, 22(2), 1087057116673607.
  2. Macarron, R. . (2015). Chemical libraries: how dark is hts dark matter?. Nature Chemical Biology, 11(12).
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