BOC Sciences provides general analysis and purification services for the clients from candidates discovering to clinical trial chemicals. Related date is provided by our analytical team throughout the development process. Our cGMP analytical laboratories facilitate integrated and efficient project support with scientific analysists actively engaging with clients and providing analyses to Formulations and Manufacturing departments.
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The majority of compounds contain certain amount of impurities and will suffer from a certain extent of degradation during production, storage and transportation. Recognizing the fact that it is inadvisable and costlier to replace these compounds just by re-synthesis or purchasing, utilizing purification techniques or chemical transformations to reclaim the pure compounds, therefore, represents an alternative approaches that is more efficient and rapid.
Although the optical isomers in a chiral compound have the same physical and chemical characteristics in general, they will exhibit marked differences in the pharmacological and toxicological activities. Chiral separation and analysis of racemic drugs is therefore of great importance in the pharmaceutical and chemical industry.
As one of the most key elements for any pharmaceutical development program, analytic method development, validation, and transfer play an essential role in many aspects such as controlling the quality, insuring the safety and improving the potency of products. These activities are interrelated and iterative particularly during early drug development phases.
Our analysis platform is based on the current instrument requirements. Special instruments are used for qualitative analysis, quantitative analysis and morphological analysis.
| 1H-NMR |
| 13C-NMR | |
| 2D-NMR | |
| Preparative HPLC |
| Analytical HPLC | |
| Chiral HPLC | |
| HRMS |
| GC and GC-MS | |
| LC-MS | |
| FTIR |
| UV-Vis | |
| Polarimeter | |
| Karl Fischer titration test | |
| Elemental analyzer | |
| X-ray powder Crystal Diffractometer |
Strict adherence to ICH and cGMP guidelines
Continuity in analytical work-training and transfer of analytical methods to Quality Control
Engagement in project management throughout the development process
Development of robust and easily transferrable methods
What are the different analytical techniques used for purification?
Common analytical techniques that support purification include high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), nuclear magnetic resonance (NMR), and infrared spectroscopy (IR). These methods help monitor purity levels, identify impurities, and confirm compound identity during purification processes.
What is the process of purification in chemical research?
Purification involves separating a target compound from impurities or byproducts using techniques such as chromatography, crystallization, distillation, or extraction. Analytical testing is often integrated to verify purity and ensure that the final product meets research specifications.
What are the methods of purification in laboratory settings?
Laboratory purification methods include preparative chromatography, recrystallization, liquid–liquid extraction, solid-phase extraction, and distillation. The choice of method depends on the chemical nature of the compound and the required purity level.
Is extraction a purification or analytical technique?
Extraction is primarily a purification technique used to separate compounds based on their solubility in different solvents. While not analytical in itself, it is often paired with analytical methods to assess the efficiency of the separation and the purity of the resulting product.
What analysis and purification capabilities does BOC Sciences provide?
BOC Sciences offers a comprehensive range of purification and analytical services, including preparative HPLC, flash chromatography, crystallization, and extraction, supported by advanced analytical tools such as LC–MS, GC–MS, NMR, and IR. These capabilities ensure accurate compound isolation and purity confirmation for diverse research applications.
We perform analysis and purification to ensure product quality, consistency, and readiness for downstream applications.
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