Antibody-Oligonucleotide Conjugation Service

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Antibody-Oligonucleotide Conjugation Service

Conjugated is the process of covalently connecting two molecules/polymers or biomolecules/ biopolymers. Studies have shown that antibody molecules have many functional groups suitable for modification or binding. Cross-linked oligonucleotides antibodies can be realized by lysine and N-terminal groups.

Application of Antibody–Oligonucleotide Conjugation

Antibody-oligonucleotides conjugate, by immobilization of the analyte of each conjugate on a solid carrier with homologous capture antibody, achieved immuno-PCR and other high sensitivity immunoassay. The binding of antibody-oligonucleotides to fixed analytes can amplify the linked DNA. The amplified products are displayed by gel electrophoresis and therefore indicate the presence of binding analytes. Antibody-oligonucleotides conjugate is an ideal tool for the detection of highly sensitive proteins. In addition, oligonucleotides antibodies are widely used in many fields from diagnosis to treatment, such as biomarker discovery, clinical diagnosis, protein interaction and so on. In addition to binding to antibodies, oligonucleotides-semi-antibody binding has also been developed for therapeutic and diagnostic applications.

Our Services

  • The production of conjugated substances ranging from 1mg to 1g as required.
  • The desired antibody-oligomerization rate conjugate.
  • Antibody clearance before binding (removal of BSA or azide).
  • If necessary, replace the antibody buffer with a “binding friendly” buffer.
  • Free oligodeoxynucleotides were removed and conjugated.
  • The one-dimensional gel was successfully bonded.
  • Simultaneously analyze multiple targets within one reaction/sample
  • Fast turnaround time.
  • PCR can be used to amplify marker DNA attached to antigen-antibody complexes.

Our Advantages

  • Executed by trained professionals.
  • The agreed conjugate rate and scale.
  • Evidence of successful bonding is provided.
  • Renewable.
  • Fast turnaround time.
  • Full technical support.
  • Suitable for other proteins.
  • Well-characterized conjugation services with full of technical support

The preparation of antibody-oligonucleotides conjugate is time-consuming and difficult. Our antibody-oligonucleotides binding services can provide you with the antibody-oligonucleotides couplings you need. In addition, we also provide other antibody binding services to meet the special requirements of each customer. If you are interested in the services we can provide and would like more detailed information, please feel free to contact us and get exclusive technical support services. Our project manager will contact you as soon as possible and help you design appropriate agreements to meet your specific requirements.

References

  1. Han, K. C., Ahn, D. R., & Yang, E. G. (2010). An Approach to Multiplexing an Immunosorbent Assay with Antibody-Oligonucleotide Conjugates. Bioconjugate chemistry21(12), 2190-2196.
  2. Vigneault, F., Briggs, A. W., Goldfless, S. J., & Belmont, B. J. (2019). U.S. Patent Application No. 15/762,446.
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